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Review
. 2023 Mar 7;12(6):1207.
doi: 10.3390/plants12061207.

Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

Vincenza Tinnirello  1 , Nima Rabienezhad Ganji  1 , Carine De Marcos Lousa  2   3 , Riccardo Alessandro  1 , Stefania Raimondo  1
Affiliations
Review

Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

Vincenza Tinnirello et al. Plants (Basel). .

Abstract

The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.

Keywords: co-incubation; drug delivery; microRNA; plant-derived nanoparticles (PDNPs); sonication.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the techniques used to date for: (left panel) the loading of exogenous substances into PDNPs; (right panel) the reassembly of lipids derived from PDNPs for the generation of natural nanovectors for use in the field of drug delivery.
See this image and copyright information in PMC

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