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. 2023 Mar 10;12(6):1262.
doi: 10.3390/plants12061262.

Chemical Constituents from Leaves of Baccharis sphenophylla (Asteraceae) and Their Antioxidant Effects

Marcela H Retamozo  1 , Christian C Silva  1 , Cinthia I Tamayose  1 , Juliana C S Carvalho  1 , Paulete Romoff  2 , Oriana A Fávero  3 , Marcelo J P Ferreira  1
Affiliations

Chemical Constituents from Leaves of Baccharis sphenophylla (Asteraceae) and Their Antioxidant Effects

Marcela H Retamozo et al. Plants (Basel). .

Abstract

Baccharis is one of the largest genera of Asteraceae and its species are used in folk medicine for several medicinal purposes due to the presence of bioactive compounds. We investigated the phytochemical composition of polar extracts of B. sphenophylla. Using chromatographic procedures, diterpenoids (ent-kaurenoic acid), flavonoids (hispidulin, eupafolin, isoquercitrin, quercitrin, biorobin, rutin, and vicenin-2), caffeic acid, and chlorogenic acid derivatives (5-O-caffeoylquinic acid and its methyl ester, 3,4-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid, and 3,5-di-O-caffeoylquinic acid and its methyl ester) were isolated from polar fractions and are described. The extract, polar fractions, and fifteen isolated compounds were evaluated in relation to radical scavenging activity using two assays. Chlorogenic acid derivatives and flavonols exhibited higher antioxidant effects, confirming that B. sphenophylla is an important source of phenolic compounds with antiradical properties.

Keywords: Baccharis sphenophylla; Compositae; antiradical activity; chlorogenic acid derivatives; flavonoids.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Photos of Baccharis sphenophylla in the field. (a) Photo of an entire specimen of B. sphenophylla in the field; (b) zoomed-in photo of the leaves and flower buds of B. sphenophylla.
Figure 2
Figure 2
Structures of compounds identified from leaves of B. sphenophylla.
See this image and copyright information in PMC

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