doi: 10.1159/000238397.
Penicillin concentrations in serum following weekly injections of benzathine penicillin G
- PMID: 3698728
- DOI: 10.1159/000238397
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Penicillin concentrations in serum following weekly injections of benzathine penicillin G
Chemotherapy.
1986.
Abstract
Twelve patients with syphilis were treated weekly with injections of 1.44 g (2.4 X 10(6) IU) of benzathine penicillin G for up to 3 weeks. Almost daily, serum penicillin concentrations were measured by a sensitive microbiological agar cup method. An individual and interindividual variation was found. Concentrations below the recommended 0.018 micrograms/ml were found 7 days after the first or second injection in 5 samples. Shorter intervals between injections are recommended.
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