Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 29;44(1):7-16.
doi: 10.2478/prilozi-2023-0002. Print 2023 Mar 1.

Effect of Supplemental Antioxidant-Based Therapy on the Oxidative Stress Level in COVID-19 Patients

Dragica Zendelovska  1 , Emilija Atanasovska  1 , Katerina Spasovska  2 , Meri Kirijas  3 , Kosta Kapsarov  2 , Dejan Jakimovski  2 , Marija Petrushevska  1
Affiliations
Free article

Effect of Supplemental Antioxidant-Based Therapy on the Oxidative Stress Level in COVID-19 Patients

Dragica Zendelovska et al. Pril (Makedon Akad Nauk Umet Odd Med Nauki). .
Free article

Abstract

Background: COVID-19 is a disease in several stages starting with virus replication to dysregulation in immune system response, organ failure and recovery/death. Our aim was to determine the effect of Ganoderma lucidum, lycopene, sulforaphane, royal jelly and resveratrol extract on markers of oxidative stress, inflammation, routine laboratory analyses and duration of symptoms in COVID-19 patients. Methods: The oxidative stress parameters and interleukines 6 and 8 (IL-6, IL-8), tumor necrosis factor alpha (TNF-α) were determined in order to estimate the antioxidant and the anti-inflammatory effect of the product using a spectrophotometric and a magnetic bead-based multiplex assay in serum of 30 patients with mild form of COVID-19. Results: Statistically significant differences were obtained for all investigated parameters between the treated patients and the control group. Moreover, significant differences were observed for leukocytes, neutrophil to leukocyte ratio and iron. The average duration of the symptoms was 9.4±0.487 days versus 13.1±0.483 days in the treatment and the control group, respectively (p=0.0003). Conclusion: Our results demonstrated the promising effect of Ge132+NaturalTM on reducing the oxidative stress and the IL-6, IL-8 and TNF-α levels, and symptoms duration in COVID-19 patients. The evidence presented herein suggest that the combination of Ganoderma lucidum extract, lycopene, sulforaphane, royal jelly and resveratrol could be used as a potent an adjuvant therapy in diseases accompanied by increased oxidative stress and inflammation.

Keywords: COVID-19; Ganoderma lucidum; Ge132+ Natural™; anti-inflammatory; lycopene; oxidative stress; resveratrol; royal jelly; sulforaphane.

PubMed Disclaimer

References

    1. https://covid19.who.int/ -accessed on 27 February 2022
    1. Li C, He Q, Qian H, Liu J. Overview of the pathogenesis of COVID 19 (Review). Exp Ther Med. 2021;22:1011.
    1. Barciszewska AM. Elucidating of oxidative distress in COVID-19 and methods of its prevention. Chemico Biol Interact. 2021;344:109501.
    1. Ntyonga-Pono MP. COVID-19 infection and oxidative stress: an under-explored approach for prevention and treatment. Pan Afr Med J. 2020;35:12.
    1. Gadotti AC, Lipinski AL, Vasconcellos FT, et al. Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease. Free Radic Biol Med. 2021;165:184-190.

LinkOut - more resources