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. 2023 Oct;19(10):4641-4650.
doi: 10.1002/alz.13054. Epub 2023 Mar 29.

Predicting cognitive stage transition using p-tau181, Centiloid, and other measures

Hyuk Sung Kwon  1 , Ji Young Kim  2 , Seong-Ho Koh  1 , Seong Hye Choi  3 , Eun-Hye Lee  1 , Jee Hyang Jeong  4 , Jae-Won Jang  5 , Kyung Won Park  6 , Eun-Joo Kim  7 , Jin Yong Hong  8 , Soo Jin Yoon  9 , Bora Yoon  10 , Hyun-Hee Park  1 , Myung Hoon Han  11
Affiliations

Predicting cognitive stage transition using p-tau181, Centiloid, and other measures

Hyuk Sung Kwon et al. Alzheimers Dement. 2023 Oct.

Abstract

Background: A combination of plasma phospho-tau (p-tau), amyloid beta (Aβ)-positron emission tomography (PET), brain magnetic resonance imaging, cognitive function tests, and other biomarkers might predict future cognitive decline. This study aimed to investigate the efficacy of combining these biomarkers in predicting future cognitive stage transitions within 3 years.

Methods: Among the participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE-V) study, 49 mild cognitive impairment (MCI) and 113 cognitively unimpaired (CU) participants with Aβ-PET and brain imaging data were analyzed.

Results: Older age, increased plasma p-tau181, Aβ-PET positivity, and decreased semantic fluency were independently associated with cognitive stage transitions. Combining age, p-tau181, the Centiloid scale, semantic fluency, and hippocampal volume produced high predictive value in predicting future cognitive stage transition (area under the curve = 0.879).

Conclusions: Plasma p-tau181 and Centiloid scale alone or in combination with other biomarkers, might predict future cognitive stage transition in non-dementia patients.

Highlights: -Plasma p-tau181 and Centiloid scale might predict future cognitive stage transition. -Combining them or adding other biomarkers increased the predictive value. -Factors that independently associated with cognitive stage transition were demonstrated.

Keywords: Alzheimer's disease; Centiloid; cognitive stage; p-tau; prognosis.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

Author disclosures are available in the supporting information.

Figures

FIGURE 1
FIGURE 1
The correlation between the level of plasma p-tau181 and the Centiloid scale
FIGURE 2
FIGURE 2
Receiver operating characteristic (ROC) curve analyses of the different models for discriminating those with cognitive stage transition in total (A), cognitive unimpaired (B), and mild cognitive impairment (C) patients. Among 162 patients, 31 show cognitive stage transition during 3 years and 134 have plasma p-tau181 data. AUC, area under curve
See this image and copyright information in PMC

References

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