The first mobile photon-counting detector CT: the human images and technical performance study

Abstract

Objective. The purpose of this study is to assess its human images and its unique capabilities such as the 'on demand' higher spatial resolution and multi-spectral imaging of photon-counting-detector (PCD)-CT.Approach. In this study, the FDA 510(k) cleared mobile PCD-CT (OmniTom Elite) was used. To this end, we imaged internationally certified CT phantoms and a human cadaver head to evaluate the feasibility of high resolution (HR) and multi-energy imaging. We also demonstrate the performance of PCD-CT via first-in-human imaging by scanning three human volunteers.Main results. At the 5 mm slice thickness, routinely used in diagnostic head CT, the first human PCD-CT images were diagnostically equivalent to the EID-CT scanner. The HR acquisition mode of PCD-CT achieved a resolution of 11 line-pairs (lp)/cm as compared to 7 lp cm^-1using the same kernel (posterior fossa-kernel) in the standard acquisition mode of EID-CT. For the quantitative multi-energy CT performance, the measured CT numbers in virtual mono-energetic images (VMI) of iodine inserts in the Gammex Multi-Energy CT phantom (model 1492, Sun Nuclear Corporation, USA) matched the manufacturer reference values with mean percent error of 3.25%. Multi-energy decomposition with PCD-CT demonstrated the separation and quantification of iodine, calcium, and water.Significance. PCD-CT can achieve multi-resolution acquisition modes without physically changing the CT detector. It can provide superior spatial resolution compared with the standard acquisition mode the conventional mobile EID-CT. Quantitative spectral capability of PCD-CT can provide accurate, simultaneous multi-energy images for material decomposition and VMI generation using a single exposure.

Keywords: PCD-CT; human images; photon-counting detector; techincal performance.