Preterm birth and asthma and COPD in adulthood: a nationwide register study from two Nordic countries

Abstract

Background: Preterm birth affects lungs in several ways but few studies have follow-up until adulthood. We investigated the association of the entire spectrum of gestational ages with specialist care episodes for obstructive airway disease (asthma and chronic obstructive pulmonary disease (COPD)) at age 18-50 years.

Methods: We used nationwide registry data on 706 717 people born 1987-1998 in Finland (4.8% preterm) and 1 669 528 born 1967-1999 in Norway (5.0% preterm). Care episodes of asthma and COPD were obtained from specialised healthcare registers, available in Finland for 2005-2016 and in Norway for 2008-2017. We used logistic regression to estimate odds ratios (ORs) for having a care episode with either disease outcome.

Results: Odds of any obstructive airway disease in adulthood for those born at <28 or 28-31 completed weeks were 2-3-fold of those born full term (39-41 completed weeks), persisting after adjustments. For individuals born at 32-33, 34-36 or 37-38 weeks, the odds were 1.1- to 1.5-fold. Associations were similar in the Finnish and the Norwegian data and among people aged 18-29 and 30-50 years. For COPD at age 30-50 years, the OR was 7.44 (95% CI 3.49-15.85) for those born at <28 weeks, 3.18 (95% CI 2.23-4.54) for those born at 28-31 weeks and 2.32 (95% CI 1.72-3.12) for those born at 32-33 weeks. Bronchopulmonary dysplasia in infancy increased the odds further for those born at <28 and 28-31 weeks.

Conclusion: Preterm birth is a risk factor for asthma and COPD in adulthood. The high odds of COPD call for diagnostic vigilance when adults born very preterm present with respiratory symptoms.

FIGURE 1

Associations between gestational age (GA) in weeks and any obstructive airway disease (asthma or chronic obstructive pulmonary disease), adjusted for sex and birth year.

FIGURE 2

Associations between gestational age (GA) in weeks and a) asthma and b) chronic obstructive pulmonary disease (COPD), adjusted for sex and birth year. ^#: missing outcome values for extremely and very preterm born in Finland.

FIGURE 3

Associations between gestational age (GA) in weeks and obstructive airway disease (asthma or chronic obstructive pulmonary disease) at age 18–29 years in children born preterm with or without a diagnosis of bronchopulmonary dysplasia (BPD). Models are adjusted for sex and birth year.

FIGURE 4

Associations between gestational age (GA) in weeks and obstructive airway disease (asthma or chronic obstructive pulmonary disease) at age 18­–29 years in different birth weight groups. Models adjusted for sex and birth year.