Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review

Ibrahim N Muhsen¹, Sebastian Galeano², Dietger Niederwieser³, Mickey B C Koh⁴, Per Ljungman⁵, Clarisse M Machado⁶, Mohamed A Kharfan-Dabaja⁷, Rafael de la Camara⁸, Yoshihisa Kodera⁹, Jeff Szer¹⁰, Walid Rasheed¹¹, Simone Cesaro¹², Shahrukh K Hashmi¹³, Adriana Seber¹⁴, Yoshiko Atsuta¹⁵, Mostafa F Mohammed Saleh¹¹, Alok Srivastava¹⁶, Jan Styczynski¹⁷, Abdulrahman Alrajhi¹⁸, Reem Almaghrabi¹⁹, Muhammad Bilal Abid²⁰, Roy F Chemaly²¹, Usama Gergis²², Eolia Brissot²³, Riad El Fakih¹¹, Marcie Riches²⁴, Malgorzata Mikulska²⁵, Nina Worel²⁶, Daniel Weisdorf²⁷, Hildegard Greinix²⁸, Catherine Cordonnier²⁹, Mahmoud Aljurf³⁰

Affiliations

¹ Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
² Department of Hematology, Hospital Británico, Montevideo, Uruguay.
³ Division of Hematology and Medical Oncology, University of Leipzig, Leipzig, Germany; Lithuanian University of Health Sciences Kauno Klinikos, Lithuania; Aichi Medical University School of Medicine, Nagakute, Japan.
⁴ Infection and Immunity Clinical Academic Group, University of London and Department of Haematology, St George's Hospital and Medical School, London, UK; Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore.
⁵ Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Comprehensive Cancer Center, Stockholm, Sweden; Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
⁶ Virology Laboratory Institute of Tropical Medicine-University of São Paulo Medical School, São Paulo, Brazil; HCT Program - Hospital Amaral Carvalho, Jahu, Brazil.
⁷ Division of Hematology-Oncology, Mayo Clinic, Jacksonville, FL, USA.
⁸ Department of Hematology, Hospital de la Princesa, Madrid, Spain.
⁹ Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute, Japan.
¹⁰ Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
¹¹ Adult Hematology and Stem Cell Transplant, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
¹² Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
¹³ Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Department of Medicine, Sheikh Shakbout Medical City, Abu Dhabi, United Arab Emirates; College of Medicine & Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.
¹⁴ Hospital Samaritano Higienópolis and Graacc - Unifesp, São Paulo, Brazil.
¹⁵ Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan; Department of Registry Science for Transplant and Cellular Therapy, Nagakute, Japan.
¹⁶ Department of Hematology, Christian Medical College, Vellore, India; Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.
¹⁷ Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.
¹⁸ Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
¹⁹ Organ Transplantation Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
²⁰ Division of Divisions of Hematology/Oncology & Infectious Diseases, BMT & Cellular Therapy Program, Milwaukee, WI, USA.
²¹ Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²² Sidney Kimmel Cancer Center, Philadelphia, PA, USA.
²³ Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Sorbonne Université, INSERM UMRs 938, Paris, France.
²⁴ Division of Hematology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
²⁵ Division of Infectious Diseases, DISSAL, University of Genova, Italy and IRCCS Ospedale Policlinico San Martino, Genova, Italy.
²⁶ Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, Vienna, Austria.
²⁷ Division of Hematology, Oncology and Transplantation, University of Minnesota, MN, USA.
²⁸ Medical University Graz, Division of Hematology, Graz, Austria.
²⁹ Haematology Department, Henri Mondor Hospital and University Paris-Est-Créteil, Créteil, France.
³⁰ Adult Hematology and Stem Cell Transplant, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: maljurf@kfshrc.edu.sa.

PMID: 36990624
DOI: 10.1016/S2352-3026(23)00031-5

Review

Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review

Ibrahim N Muhsen et al. Lancet Haematol. 2023 Apr.

. 2023 Apr;10(4):e295-e305.

doi: 10.1016/S2352-3026(23)00031-5.

Authors

Affiliations

¹ Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
² Department of Hematology, Hospital Británico, Montevideo, Uruguay.
³ Division of Hematology and Medical Oncology, University of Leipzig, Leipzig, Germany; Lithuanian University of Health Sciences Kauno Klinikos, Lithuania; Aichi Medical University School of Medicine, Nagakute, Japan.
⁴ Infection and Immunity Clinical Academic Group, University of London and Department of Haematology, St George's Hospital and Medical School, London, UK; Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore.
⁵ Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Comprehensive Cancer Center, Stockholm, Sweden; Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
⁶ Virology Laboratory Institute of Tropical Medicine-University of São Paulo Medical School, São Paulo, Brazil; HCT Program - Hospital Amaral Carvalho, Jahu, Brazil.
⁷ Division of Hematology-Oncology, Mayo Clinic, Jacksonville, FL, USA.
⁸ Department of Hematology, Hospital de la Princesa, Madrid, Spain.
⁹ Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute, Japan.
¹⁰ Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
¹¹ Adult Hematology and Stem Cell Transplant, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
¹² Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
¹³ Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Department of Medicine, Sheikh Shakbout Medical City, Abu Dhabi, United Arab Emirates; College of Medicine & Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.
¹⁴ Hospital Samaritano Higienópolis and Graacc - Unifesp, São Paulo, Brazil.
¹⁵ Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan; Department of Registry Science for Transplant and Cellular Therapy, Nagakute, Japan.
¹⁶ Department of Hematology, Christian Medical College, Vellore, India; Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.
¹⁷ Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.
¹⁸ Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
¹⁹ Organ Transplantation Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
²⁰ Division of Divisions of Hematology/Oncology & Infectious Diseases, BMT & Cellular Therapy Program, Milwaukee, WI, USA.
²¹ Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²² Sidney Kimmel Cancer Center, Philadelphia, PA, USA.
²³ Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Sorbonne Université, INSERM UMRs 938, Paris, France.
²⁴ Division of Hematology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
²⁵ Division of Infectious Diseases, DISSAL, University of Genova, Italy and IRCCS Ospedale Policlinico San Martino, Genova, Italy.
²⁶ Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, Vienna, Austria.
²⁷ Division of Hematology, Oncology and Transplantation, University of Minnesota, MN, USA.
²⁸ Medical University Graz, Division of Hematology, Graz, Austria.
²⁹ Haematology Department, Henri Mondor Hospital and University Paris-Est-Créteil, Créteil, France.
³⁰ Adult Hematology and Stem Cell Transplant, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: maljurf@kfshrc.edu.sa.

PMID: 36990624
DOI: 10.1016/S2352-3026(23)00031-5

Abstract

There is a scarcity of data on endemic and regionally limited fungal and parasitic infections in recipients of haematopoietic stem-cell transplantation (HSCT) outside western Europe and North America. This Worldwide Network for Blood and Marrow Transplantation (WBMT) Review is one of two papers aiming to provide guidance to transplantation centres worldwide regarding prevention, diagnosis, and treatment based on the currently available evidence and expert opinion. These recommendations were created and reviewed by physicians with expertise in HSCT or infectious disease, representing several infectious disease and HSCT groups and societies. In this paper, we review the literature on several endemic and regionally limited parasitic and fungal infections, some of which are listed as neglected tropical diseases by WHO, including visceral leishmaniasis, Chagas disease, strongyloidiasis, malaria, schistosomiasis, histoplasmosis, blastomycosis, and coccidioidomycosis.

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Conflict of interest statement

Declaration of interests MBCK declares honoraria from Gilead and an advisory board role at Gilead. RDLC declares honoraria from Gilead. NW: declares honoraria from Novartis, Kite Gilead, Sanofi Genzyme, and Therakos Mallinckrodt; consultancy fees from Novartis; travel fees from Kite Gilead and BMS Celgene; research funding from Sanofi Genzyme; and speaker fees from Therakos Mallinckrodt. EB declares honoraria from Novartis, Astellas, Alexion, Jazz Pharmaceuticals, Gilead, MSD, Keocyt, and Amgen; and travel fees from Novartis, Jazz Pharmaceuticals, and Amgen. JeS declares consultancy fees from Alexion, Sobi, and Takeda; honoraria from Alexion, Sobi, and Takeda; travel fees from Sobi; and an advisory board role at Prevail Therapeutics. JaS declares honoraria from MSD, Glead, TEVA, Atara, and Takeda. DW declares research funding from FATE therapeutics and Incyte. SKH declares honoraria from Pfizer, Novartis, Janssen, Therakos Mallinckrodt, Sanofi, and Roche. All other authors declare no competing interests.

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Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review

Affiliations

Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review

Authors

Affiliations

Abstract

Conflict of interest statement

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Medical