Comparison between VP 16 and VM 26 in Lewis lung carcinoma of the mouse
- PMID: 3699080
- DOI: 10.1016/0277-5379(86)90027-1
Comparison between VP 16 and VM 26 in Lewis lung carcinoma of the mouse
Abstract
The antitumoral activity and pharmacokinetics of VP 16 and VM 26 were comparatively investigated in Lewis lung carcinoma (3LL)-bearing mice. When the two drugs were given at equitoxic doses, in single or repeated treatment, the superior antitumoral activity of VM 26 was clear. Compared to VP 16, VM 26 had a different pattern of distribution, with a larger volume of distribution, a longer elimination half-life time and a lower clearance. The tissue to plasma AUC ratios indicated that VM 26 concentrated more in tumor and heart while VP 16 gave highest concentrations in liver and intestine. Flow cytometry studies showed that VM 26 was more potent than VP 16 in causing cell cycle perturbation of 3LL cells growing in primary culture. VM 26 displayed cytotoxic activity at a concentration in the medium one-tenth that of VP 16. The uptake of VM 26 by 3LL cells was 15 times that of VP 16.
Similar articles
-
Activity and pharmacokinetics of teniposide in Lewis lung carcinoma-bearing mice.Cancer Treat Rep. 1983 Jun;67(6):555-9. Cancer Treat Rep. 1983. PMID: 6861161
-
The epipodophyllotoxin derivatives VM-26 and VP-16-213, 1976-1979, a review.Recent Results Cancer Res. 1980;74:98-106. doi: 10.1007/978-3-642-81488-4_14. Recent Results Cancer Res. 1980. PMID: 7003663 Review.
-
The effect of the two epipodophyllotoxin derivatives etoposide (VP-16) and teniposide (VM-26) on cell lines established from patients with small cell carcinoma of the lung.Cancer Chemother Pharmacol. 1987;19(1):16-20. doi: 10.1007/BF00296248. Cancer Chemother Pharmacol. 1987. PMID: 3815721
-
Skin ulceration potential without therapeutic anticancer activity for epipodophyllotoxin commercial diluents.Invest New Drugs. 1983;1(2):151-9. doi: 10.1007/BF00172074. Invest New Drugs. 1983. PMID: 6678864
-
VM 26 and VP 16-213: a comparative analysis.Cancer. 1977 Jul;40(1):334-42. doi: 10.1002/1097-0142(197707)40:1<334::aid-cncr2820400147>3.0.co;2-x. Cancer. 1977. PMID: 328129 Review.
Cited by
-
Mitozolomide activity on human cancer cells in vitro.Br J Cancer. 1986 Dec;54(6):925-32. doi: 10.1038/bjc.1986.263. Br J Cancer. 1986. PMID: 3801288 Free PMC article.
-
Pharmacokinetics of VM 26 given intrapericardially or intravenously in patients with malignant pericardial effusion.Cancer Chemother Pharmacol. 1987;20(3):239-42. doi: 10.1007/BF00570493. Cancer Chemother Pharmacol. 1987. PMID: 2824081
-
Pharmacokinetics of anticancer drugs in children.Clin Pharmacokinet. 1987 Mar;12(3):168-213. doi: 10.2165/00003088-198712030-00002. Clin Pharmacokinet. 1987. PMID: 3555940 Review.
-
The clinical pharmacology of etoposide and teniposide.Clin Pharmacokinet. 1987 Apr;12(4):223-52. doi: 10.2165/00003088-198712040-00001. Clin Pharmacokinet. 1987. PMID: 3297462 Review.
-
Etoposide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer.Drugs. 1990 Mar;39(3):438-90. doi: 10.2165/00003495-199039030-00008. Drugs. 1990. PMID: 2184009 Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical