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. 2023 Mar 17;15(3):770.
doi: 10.3390/v15030770.

Vector Competence for Zika Virus Changes Depending on the Aedes aegypti's Region of Origin in Manaus: A Study of an Endemic Brazilian Amazonian City

Andréia da Costa Paz  1   2 , Bárbara Aparecida Chaves  1   2   3 , Raquel Soares Maia Godoy  3   4 , Deilane Ferreira Coelho  1 , Ademir Bentes Vieira Júnior  1   2 , Rodrigo Maciel Alencar  1   2 , João Arthur Alcântara  1   2 , Luiza Dos Santos Félix  3   4 , Cinthia Catharina Azevedo Oliveira  3   4 , Wuelton Marcelo Monteiro  1   2 , Marcus Vinicius Guimarães Lacerda  1   2   5   6 , Nágila Francinete Costa Secundino  1   2   3   4 , Paulo Filemon Paolucci Pimenta  1   2   3   4
Affiliations

Vector Competence for Zika Virus Changes Depending on the Aedes aegypti's Region of Origin in Manaus: A Study of an Endemic Brazilian Amazonian City

Andréia da Costa Paz et al. Viruses. .

Abstract

Zika virus (ZIKV) is transmitted to humans by the infectious bite of mosquitoes such as Aedes aegypti. In a city, the population control of mosquitoes is carried out according to alerts generated by different districts via the analysis of the mosquito index. However, we do not know whether, besides mosquito abundance, the susceptibility of mosquitoes could also diverge among districts and thus impact the dissemination and transmission of arboviruses. After a viremic blood meal, the virus must infect the midgut, disseminate to tissues, and reach the salivary gland to be transmitted to a vertebrate host. This study evaluated the patterns of ZIKV infection in the Ae. aegypti field populations of a city. The disseminated infection rate, viral transmission rate, and transmission efficiency were measured using quantitative PCR at 14 days post-infection. The results showed that all Ae. aegypti populations had individuals susceptible to ZIKV infection and able to transmit the virus. The infection parameters showed that the geographical area of origin of the Ae. aegypti influences its vector competence for ZIKV transmission.

Keywords: Zika virus; disseminated infection rate; field mosquito population; infection rate; transmission efficiency; vector competence.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Map of Manaus showing the five districts where the mosquitoes were collected in the field (A). Infection rates (B) and disseminated infection rates (C) of Aedes aegypti mosquitoes from 5 districts of Manaus for transmitting Zika virus at 14 days post-infection.
Figure 2
Figure 2
ZIKV viral loads (VLs) per body (A) and head/salivary gland (B) in Ae. aegypti populations from the five districts of Manaus. The VLs were measured as cDNA copies by qPCR at 14 days post-infection. Transmission rate (C) and transmission efficiency (D) of the 5 Ae. aegypti populations from Manaus for ZIKV at 14 days post-infection. The p values 0.05 and 0.01 are summarized with one (*) and two (**) asterisks, respectively.
See this image and copyright information in PMC

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