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Comment
. 2023 Mar;3(3):246-247.
doi: 10.1038/s43587-023-00378-1. Epub 2023 Feb 13.

Shared and disease-specific glial gene expression changes in neurodegenerative diseases

Guoyan Zhao  1
Affiliations
Comment

Shared and disease-specific glial gene expression changes in neurodegenerative diseases

Guoyan Zhao. Nat Aging. 2023 Mar.

Abstract

We found evolutionarily conserved astrocyte and microglia subpopulations shared across multiple brain regions. We reveal similarities and differences between Alzheimer's disease glia and Parkinson's disease glia, as well as regional variance linked to disease pathology and neurodegeneration.

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Figures

Fig. 1 |
Fig. 1 |. Three astrocyte and two microglia subpopulations shared across different brain regions.
a–f, Unsupervised clustering of single-nucleus RNA-seq data and uniform manifold approximation and projection (UMAP) visualization of astrocyte (a,c,e) and microglia (b,d,f) subpopulations, colored by cluster identity, for putamen, entorhinal cortex and prefrontal cortex. Microglia subpopulations are also colored by inferred pseudotime values (black–blue scale, starting from 0 representing the earliest pseudotime). Black lines represent inferred pseudotime trajectories. © 2023, Xu, J. et al.
See this image and copyright information in PMC

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