Innate lymphoid cells type 2 and CD8⁺ T cells are perturbed in overweight and obese individuals with asthma

Sophia Björkander¹, Paul Maier², Maura Kere¹, Simon Kebede Merid¹, Lorenz Wirth³, Whitney Wiegel², Sandra Ekström^{4

5}, Inger Kull^{1

6}, Anna Bergström^{4

5}, Erik Melén^{1

6}, Jenny Mjösberg^{2

7}, Christopher Andrew Tibbitt^{2

7}

Affiliations

¹ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
² Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
³ Mechanistic & Structural Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
⁴ Centre for Occupational and Environmental Medicine, Stockholm, Sweden.
⁵ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
⁶ Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden.
⁷ Clinical Lung- and Allergy Research Unit, Medical unit for Lung and Allergy Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Sophia Björkander et al. Allergy. 2023 Sep.

. 2023 Sep;78(9):2533-2536.

doi: 10.1111/all.15728. Epub 2023 Apr 7.

¹ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
² Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
³ Mechanistic & Structural Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
⁴ Centre for Occupational and Environmental Medicine, Stockholm, Sweden.
⁵ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
⁶ Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden.
⁷ Clinical Lung- and Allergy Research Unit, Medical unit for Lung and Allergy Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden.

No abstract available

References

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1. Björkander S, Du L, Zuo F, et al. SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults. J Allergy Clin Immunol. 2022;149:65-75.e8.
1. Pereira BI, de Maeyer RPH, Covre LP, et al. Sestrins induce natural killer function in senescent-like CD8+ T cells. Nat Immunol. 2020;21:684-694.