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. 2023 Aug;44(4):321-326.
doi: 10.1080/13816810.2023.2189948. Epub 2023 Mar 30.

Ten things you learned in your residency about retinoblastoma that have changed the 2023 Victor T. Curtin Lecture

David H Abramson  1   2
Affiliations

Ten things you learned in your residency about retinoblastoma that have changed the 2023 Victor T. Curtin Lecture

David H Abramson. Ophthalmic Genet. 2023 Aug.

Abstract

Retinoblatoma is now the pediatric cancer with the highest cure rate. More than any other ocular malignancy the approach to this cancer has changed dramatically in the past 10 years. Most of the things taught to the majority of all Ophthalmology residents is out of date. Because few Ophthalmologists deal with retinoblastoma they are not aware of these seismic changes so this summary of my Curtin lectures outlines some of the major changes all Ophthalmologists should be familiar with.

Keywords: PGD; RB1; Retinoblastoma; cancer; choroidal invasion; intraarterial chemotherapy; intravitreal chemotherapy; melphalan; radiation.

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Figures

Figure 1:
Figure 1:
Before (left) and after (right) intraarterial chemotherapy
Figure 2:
Figure 2:
PGD: Pre Implantation Genetic Diagnosis
Figure 3:
Figure 3:
Second Cancers in Retinoblastoma Survivors
See this image and copyright information in PMC

References

    1. Dimaras H, Corson TW, Cobrinik D, White A, Zhao J, Munier FL, et al. Retinoblastoma. Nat Rev Dis Primers. 2015;1:15021. - PMC - PubMed
    1. Munier FL, Beck-Popovic M, Chantada GL, Cobrinik D, Kivelä TT, Lohmann D, et al. Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”. Prog Retin Eye Res. 2019;73:100764. - PubMed
    1. Lu JE, Francis JH, Dunkel IJ, Shields CL, Yu MD, Berry JL, et al. Metastases and death rates after primary enucleation of unilateral retinoblastoma in the USA 2007–2017. Br J Ophthalmol. 2019;103(9):1272–7. - PMC - PubMed
    1. Abramson DH, Fabius AW, Issa R, Francis JH, Marr BP, Dunkel IJ, et al. Advanced Unilateral Retinoblastoma: The Impact of Ophthalmic Artery Chemosurgery on Enucleation Rate and Patient Survival at MSKCC. PLoS One. 2015;10(12):e0145436. - PMC - PubMed
    1. Abramson DH. The focal treatment of retinoblastoma with emphasis on xenon arc photocoagulation. Acta Ophthalmol Suppl (1985). 1989;194:3–63. - PubMed

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