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. 2023 Jul;280(7):3087-3095.
doi: 10.1007/s00405-023-07941-x. Epub 2023 Mar 30.

Scoping review of the relationship between xerostomia and voice quality

Mohammad Ali Saghiri  1   2 , Anna Vakhnovetsky  3 , Julia Vakhnovetsky  4   5
Affiliations

Scoping review of the relationship between xerostomia and voice quality

Mohammad Ali Saghiri et al. Eur Arch Otorhinolaryngol. 2023 Jul.

Abstract

Purpose: This scoping review aims to synthesize all of the currently available information on how xerostomia correlates with vocal function and the mechanisms that underpin it.

Methods: Our scoping review used PubMed, Scopus, Embase, and Web of Science databases to review articles published between January 1999 and July 2022 in accordance with the PRISMA-ScR guidelines. In addition to the academic databases, we also conducted a manual search of Google Scholar. Further investigation was conducted on studies that examined the relationship between xerostomia and vocal function.

Results: Of the 682 initially identified articles, 21 met our inclusion criteria. Among the included studies, two articles (n = 2) revealed the mechanistic relationship between xerostomia and vocal function. Most studies (n = 12) focused on xerostomia secondary to other underlying conditions or treatments, among which radiotherapy and Sjögren's syndrome were commonly investigated. Seven studies (n = 7) provided details about common vocal parameters measured in studies of xerostomia and the voice.

Conclusion: The literature currently lacks publications regarding the relationship between xerostomia and vocal function. Most of the studies included in this review were about xerostomia secondary to other conditions or medical treatments. Therefore, the impacts on the voice that were observed were very multifaceted and the role of xerostomia alone in phonation could not be ascertained. Nevertheless, it is clear that dryness in the mouth plays some role in vocal function and further research should focus on clarifying and finding the underlying mechanism behind this relationship by incorporating high-speed imaging and cepstral peak prominence analyses.

Keywords: Phonation; Radiotherapy; Sjögren’s syndrome; Voice; Xerostomia.

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Comment in

  • Xerostomia, sticky saliva and dysphonia.
    Rodriguez A, Maniaci A, Vaira LA, Saussez S, Lechien JR. Rodriguez A, et al. Eur Arch Otorhinolaryngol. 2023 Nov;280(11):5147-5148. doi: 10.1007/s00405-023-08171-x. Epub 2023 Aug 5. Eur Arch Otorhinolaryngol. 2023. PMID: 37542563 No abstract available.

References

    1. Nederfors T (2000) Xerostomia and hyposalivation. Adv Dent Res 14(1):48–56 - DOI - PubMed
    1. Vivino FB (2017) Sjogren’s syndrome: clinical aspects. Clin Immunol 182:48–54 - DOI - PubMed
    1. Brito-Zerón P et al (2016) Sjögren syndrome. Nat Rev Disease Primers 2(1):16047 - DOI - PubMed
    1. Liu B et al (2012) Xerostomia and salivary hypofunction in vulnerable elders: prevalence and etiology. Oral Surg Oral Med Oral Pathol Oral Radiol 114(1):52–60 - DOI - PubMed
    1. Mercadante V et al (2017) Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: a systematic review and meta-analysis. Oral Oncol 66:64–74 - DOI - PubMed

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