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Case Reports
. 2024 Jul 1;18(4):507-511.
doi: 10.1097/ICB.0000000000001423.

HIGH-RESOLUTION IMAGING OF THE OUTER RETINA IN TYPE 2 ACUTE MACULAR NEURORETINOPATHY

Nathan Doble  1   2 , Elaine M Wells-Gray  1 , Matthew P Ohr  2 , Stacey S Choi  1   2
Affiliations
Case Reports

HIGH-RESOLUTION IMAGING OF THE OUTER RETINA IN TYPE 2 ACUTE MACULAR NEURORETINOPATHY

Nathan Doble et al. Retin Cases Brief Rep. .

Abstract

Purpose: The purpose of this study was to investigate the outer retinal changes in a patient with type 2 acute macular neuroretinopathy (AMN).

Methods: A 35-year-old White woman complaining of a unilateral blind spot was imaged using various retinal imaging modalities including clinical optical coherence tomography (OCT), OCT-angiography, fundus fluorescein angiography, and adaptive optics (AO).

Results: Fundus examination revealed multiple paracentral reddish brown petaloid lesions in the symptomatic left eye, while the other eye was unremarkable. Clinical OCT showed areas of hyperreflectance at the outer plexiform layer/outer nuclear layer complex with a disrupted inner/outer segment junction, which are characteristic features of type 2 AMN. AO imaging further revealed either shortening or absence of cone outer segments within the AMN lesions attributing to the darker features observed in the en face images from fundus photography and scanning laser ophthalmoscopy.

Conclusion: The AO findings indicate that the petaloid lesions in type 2 AMN are caused by a combination of the shortening and absence of the outer segment in individual cone photoreceptors.

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Conflict of interest statement

The authors have no relevant financial interests and no potential conflicts of interest to disclose.

References

    1. Bos PJ, Deutman AF. Acute macular neuroretinopathy. Am J Ophthalmol 1975;80:573–584.
    1. Bhavsar KV, Lin S, Rahimy E, et al. Acute Macular Neuroretinopathy: a comprehensive review of the literature. Surv Ophthalmol 2016;61:538–565.
    1. Sarraf D, Rahimy E, Fawzi AA, et al. Paracentral acute middle maculopathy: a new variant of acute macular neuroretinopathy associated with retinal capillary ischemia. JAMA Ophthalmol 2013;131:1275–1287.
    1. Wells-Gray EM, Choi SS, Zawadzki RJ, et al. Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope. J Biomed Opt 2018;23:1–15.
    1. Mrejen S, Pang CE, Sarraf D, et al. Adaptive optics imaging of cone mosaic abnormalities in acute macular neuroretinopathy. Ophthalmic Surg Lasers Imaging Retina 2014;45:562–569.

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