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Case Reports
. 2023 Apr:105:108035.
doi: 10.1016/j.ijscr.2023.108035. Epub 2023 Mar 28.

Penis metastasis in colon cancer: A case report of an unusual site of dissemination

Francisco Tustumi  1 , Lucas Soares Gerbasi  2 , Rafael Vaz Pandini  2 , Marleny Novaes Figueiredo de Araujo  2 , Victor Edmond Seid  2 , Sérgio Eduardo Alonso Araujo  2
Affiliations
Case Reports

Penis metastasis in colon cancer: A case report of an unusual site of dissemination

Francisco Tustumi et al. Int J Surg Case Rep. 2023 Apr.

Abstract

Introduction and importance: Colorectal cancer is a leading cause of cancer-related deaths worldwide. It is estimated that approximately 1.93 million new cases of colorectal cancer were diagnosed and almost one million global colorectal cancer-caused deaths in 2020. The incidence of colorectal cancer has been dramatically rising at alarming rates worldwide in the last decades. The most often sites of metastases are lymph nodes, liver, lung, and peritoneum.

Case presentation: We present a rare case of a 63-year-old male patient presenting with a nodule in the penis after being treated for cancer in the hepatic flexure of the colon. Biopsy showed colorectal cancer recurrence in the penis.

Clinical discussion: Metastasis from colorectal cancer to the penis is rare and poorly discussed, with scarce data in the literature.

Conclusion: A high level of suspicion should be adopted for the correct diagnosis and early treatment.

Keywords: Colonic neoplasm; Neoplasm metastasis; Penile neoplasm; Penis.

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Conflict of interest statement

Declaration of competing interest None.

Figures

Fig. 1
Fig. 1
Computed tomography showed a massive neoplasm in the hepatic flexure of the colon and prominent ileocecal lymph nodes.
Fig. 2
Fig. 2
Penile ultrasonography showed a small thick cystic formation, with slightly thickened walls, without flow on the color study, located in the subcutaneous tissue.
Fig. 3
Fig. 3
Computed tomography showed enlarged and heterogeneous bilateral inguinal lymph nodes.
Fig. 4
Fig. 4
Magnetic resonance imaging showed enlarged and heterogeneous bilateral inguinal lymph nodes. No penile tumor could be detected with this imaging method.
Fig. 5
Fig. 5
Penile tumor histologic examination showed infiltration of the fibrous connective tissue by epithelial neoplasia with an acinar pattern, extensive mucinous differentiation, mucin lakes, areas of desmoplasic reaction, and intermingled chronic inflammatory infiltrate. Negative margins of resection.
Supplementary File 1
Supplementary File 1
The penile tumor immunohistochemistry study suggested colorectal cancer metastasis, with Cytokeratin 20, CDX-2, and SATB2 positive.
See this image and copyright information in PMC

References

    1. Xi Y., Xu P. Global colorectal cancer burden in 2020 and projections to 2040. Transl. Oncol. 2021;14(10) - PMC - PubMed
    1. Haggar FA, Boushey RP (n.d.). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clinics in colon and rectal surgery. - PMC - PubMed
    1. Allemani C., Matsuda T., Di Carlo V., Harewood R., Matz M., Nikšić M., Bonaventure A., Valkov M., Johnson C.J., Estève J., Ogunbiyi O.J. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391(10125):1023–1075. - PMC - PubMed
    1. Stintzing S. Management of colorectal cancer. F1000prime Rep. 2014:6. - PMC - PubMed
    1. Fakih M.G. Metastatic colorectal cancer: current state and future directions. J. Clin. Oncol. 2015;33(16):1809–1824. - PubMed

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