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Review
. 2023 Apr 29;401(10386):1459-1472.
doi: 10.1016/S0140-6736(22)02609-5. Epub 2023 Mar 27.

Age-related macular degeneration

Robyn H Guymer  1 , Thomas G Campbell  2
Affiliations
Review

Age-related macular degeneration

Robyn H Guymer et al. Lancet. .

Abstract

Age-related macular degeneration is an increasingly important public health issue due to ageing populations and increased longevity. Age-related macular degeneration affects individuals older than 55 years and threatens high-acuity central vision required for important tasks such as reading, driving, and recognising faces. Advances in retinal imaging have identified biomarkers of progression to late age-related macular degeneration. New treatments for neovascular age-related macular degeneration offer potentially longer-lasting effects, and progress is being made towards a treatment for atrophic late age-related macular degeneration. An effective intervention to slow progression in the earlier stages of disease, or to prevent late age-related macular degeneration development remains elusive, and our understanding of underlying mechanistic pathways continues to evolve.

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Conflict of interest statement

Declaration of interests RHG is a member of the advisory board of Bayer, Novartis, Apellis Pharmaceuticals, and Roche–Genentech; and reports honoraria from Apellis Pharmaceuticals, Bayer, and Novartis; consulting fees from Roche–Genentech; and receipt of loaned equipment from Zeiss. TGC reports being a director of the charitable NQ Eye Foundation and Kumu; payment for lectures from Medical Indemnity Protection Society; and salary support from Bayer through an unrestricted educational grant paid to the Centre for Eye Research Australia.

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