Six polyacetylenes from Atractylodes macrocephala Koidz and their anti-colon cancer activity

Tianqi Chen¹, Xiuqin Zheng¹, Limin Ouyang¹, Zhuzhen Han², Yingbo Yang¹, Lihua Gu³, Li Yang⁴, Zhengtao Wang⁴

Affiliations

¹ The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
² The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China. Electronic address: hltang@126.com.
³ The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China. Electronic address: lhgu@shutcm.edu.cn.
⁴ The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.

PMID: 36996944
DOI: 10.1016/j.fitote.2023.105490

Six polyacetylenes from Atractylodes macrocephala Koidz and their anti-colon cancer activity

Tianqi Chen et al. Fitoterapia. 2023 Jun.

. 2023 Jun:167:105490.

doi: 10.1016/j.fitote.2023.105490. Epub 2023 Mar 28.

Authors

Tianqi Chen¹, Xiuqin Zheng¹, Limin Ouyang¹, Zhuzhen Han², Yingbo Yang¹, Lihua Gu³, Li Yang⁴, Zhengtao Wang⁴

Affiliations

¹ The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
² The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China. Electronic address: hltang@126.com.
³ The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China. Electronic address: lhgu@shutcm.edu.cn.
⁴ The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.

PMID: 36996944
DOI: 10.1016/j.fitote.2023.105490

Abstract

Six undescribed polyacetylenes Atracetylenes A-F (1-6) and three known ones (7-9) were isolated from the rhizomes of Atractylodes macrocephala Koidz.. The comprehensive interpretation of NMR, HR-ESI-MS, DP4+ calculations, and electronic circular dichroism (ECD) calculations resulted in the elucidation of their structures and absolute configurations. The anti-colon cancer activities of (1-9) were evaluated by assaying the cytotoxicity and apoptosis on CT-26 cell lines. Notably, 5 (IC₅₀ 17.51 ± 1.41 μM) and 7 (IC₅₀ 18.58 ± 1.37 μM) exhibited significant cytotoxicity, and polyacetylenes 3-6 showed excellent abilities to promote apoptosis of CT-26 cell lines by Annexin V-FITC/PI assay. The results demonstrated that the polyacetylenes in A. macrocephala may be prospective for the treatment of colorectal cancer.

Keywords: Atracetylenes A-F; Atractylodes macrocephala Koidz.; CT-26 cell lines; Cytotoxicity, apoptosis; Polyacetylenes.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

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Six polyacetylenes from Atractylodes macrocephala Koidz and their anti-colon cancer activity

Affiliations

Six polyacetylenes from Atractylodes macrocephala Koidz and their anti-colon cancer activity

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous