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Observational Study
. 2023 May-Jun;40(3):472-475.
doi: 10.1111/pde.15308. Epub 2023 Mar 30.

Pediatric vulvar lichen sclerosus: Does it resolve or does it persist after menarche?

Veronica Boero  1 , Riccardo Cavalli  2 , Carlotta Caia  1   3 , Alfredo Berrettini  4 , Giulia Emily Cetera  1   3 , Ermelinda Monti  1 , Giussy Barbara  1   3 , Giorgia Carlotta Albertini  1   3 , Elisa Restelli  1 , Giada Libutti  1 , Tiziano Motta  1 , Caterina Lazzari  1   3 , Paolo Vercellini  1   3
Affiliations
Free article
Observational Study

Pediatric vulvar lichen sclerosus: Does it resolve or does it persist after menarche?

Veronica Boero et al. Pediatr Dermatol. 2023 May-Jun.
Free article

Abstract

Background and objectives: Although data regarding the rates of remission and progression of the disease are still scarce, it is generally now acknowledged that pediatric vulvar lichen sclerosus (pVLS) can persist beyond puberty. Recent studies reveal that this condition may persist in as many as 75% of cases. The present study aims to answer the following query: how does pVLS evolve after menarche?

Methods: This observational retrospective study conducted on premenarchal girls diagnosed with pVLS in our institution between 1990 and 2011 describes 31 patients who returned for multidisciplinary clinical evaluation following menarche.

Results: The mean follow-up time was 14 years. At the post-menarche clinical examination, patients were classified as follows: 58% were still affected by VLS, 16% presented with a complete remission of disease, and 26% were completely asymptomatic although with persistent clinical signs of VLS.

Conclusions: In our series, pVLS persists following menarche in the majority of patients. These findings suggest the importance of a long-term follow-up even among patients who report resolution of symptoms following menarche.

Keywords: adolescent; lichen sclerosus and atrophicus; pediatric; vulvar lichen sclerosus.

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References

REFERENCES

    1. Kumar KS, Morrel B, van Hees CLM, van der Toorn F, van Dorp W, Mendels EJ. Comparison of lichen sclerosus in boys and girls: a systematic literature review of epidemiology, symptoms, genetic background, risk factors, treatment, and prognosis. Pediatr Dermatol. 2022;39(3):400-408. doi:10.1111/pde.14967
    1. Topal IO, Tülay Sayilgan A, Kalçin S. An uncommon cause of vulval pruritus in childhood: lichen sclerosus. Turk Pediatri Ars. 2014;89(1):86-87. doi:10.5152/tpa.2014.1365
    1. Jensen LS, Bygum A. Childhood lichen sclerosus is a rare but important diagnosis. Dan Med J. 2012;59(5):A4424.
    1. Leis M, Singh A, Li C, Ahluwalia R, Fleming P, Lynde CW. Risk of vulvar squamous cell carcinoma in lichen sclerosus and lichen planus: a systematic review. J Obstet Gynaecol Can. 2022;44(2):182-192. doi:10.1016/j.jogc.2021.09.023 Epub 2021.
    1. Akbaş A, Kılınç F. Clinic and demographic characteristics of pediatric patients with lichen sclerosus. Turk J Ped. 2021;63:126-135. doi:10.24953/turkjped.2021.01.015

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