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Review
. 2023 Mar 14:13:1150777.
doi: 10.3389/fonc.2023.1150777. eCollection 2023.

A review of treatments targeting DNA-repair gene defects in metastatic castration resistant prostate cancer

Diana V Maslov  1 , Quinne Sember  1 , Jason Cham  2 , Munveer Bhangoo  1
Affiliations
Review

A review of treatments targeting DNA-repair gene defects in metastatic castration resistant prostate cancer

Diana V Maslov et al. Front Oncol. .

Abstract

Prostate cancer is the most common cancer in men. About 6% of those diagnosed will develop metastatic disease. Unfortunately, metastatic prostate cancer is fatal. Prostate cancer can be castration sensitive or castration resistant. Many treatments have been shown to improve progression free survival and overall survival in metastatic castration resistant prostate cancer (mCRPC). In recent years, studies have been exploring targeting mutations in the DNA Damage Repair (DDR) response that may amplify oncogenes. In this paper, we aim to discuss DDR, new approved targeted therapies, and the most recent clinical trials in the setting of metastatic CRPC.

Keywords: DNA damage (DDR); castration refractory prostate cancer (CRPC); metastatic; prostate cancer; target therapeutics.

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Conflict of interest statement

JC is supported by the linked award KL2TR002552. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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