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. 2024 Aug;38(15):2603-2608.
doi: 10.1080/14786419.2023.2193746. Epub 2023 Mar 31.

Parmoferone A, a new depsidone from the lichen Parmotrema cristiferum

Thuc-Huy Duong  1 , Tran Nguyen Minh An  2 , Thi-Kim-Dung Le  1 , Thi-Minh-Dinh Tran  3 , Huy Truong Nguyen  4 , Thi Hong Anh Nguyen  5 , Ngoc-Hong Nguyen  6 , Jirapast Sichaem  7
Affiliations

Parmoferone A, a new depsidone from the lichen Parmotrema cristiferum

Thuc-Huy Duong et al. Nat Prod Res. 2024 Aug.

Abstract

A new depsidone, parmoferone A (1), together with three known compounds, parmosidone K (2), albifolione (3), and 4-chloroorcinol (4) were isolated from the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae). The structures of isolated compounds were identified from its spectroscopic data and by comparison with the literature. Compounds 1-4 were evaluated for alpha-glucosidase inhibition. Compound 1 was determined to be a potent non-competitive inhibitor against alpha-glucosidase with an IC50 value of 18.1 μM.

Keywords: Parmeliaceae; Parmotrema cristiferum; alpha-glucosidase inhibition; depsidone; parmoferone A.

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