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. 2023 Apr;68(4):456-458.
doi: 10.1165/rcmb.2022-0430LE.

A Between-Sex Comparison of the Genomic Architecture of Asthma

Joe G Zein  1 , Peter Bazeley  1 , Deborah Meyers  2 , Eugene Bleecker  2 , Benjamin Gaston  3 , Bo Hu  1 , Amy Attaway  1 , Victor Ortega  4
Affiliations

A Between-Sex Comparison of the Genomic Architecture of Asthma

Joe G Zein et al. Am J Respir Cell Mol Biol. 2023 Apr.
No abstract available

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Figures

Figure 1.
Figure 1.
Manhattan plot of results of genome-wide association testing are shown for (A) female, and (B) male UK Biobank participants. The horizontal line indicates the stringent genome-wide significance threshold (P < 5 × 10−8).
Figure 2.
Figure 2.
Estimated effect sizes stratified by sex. The size of each marker reflects confidence intervals (with height reflecting the confidence interval along the y-axis and width reflecting the confidence interval along the x-axis). Comparisons reaching P < 0.05 are labeled and colored in red. BTNL2 = Butyrophilin Like 2; FLG-AS1 = Filaggrin Antisense RNA 1; HLA-DPA1 = Major Histocompatibility Complex, Class II, DP Alpha 1; HLA-DQA1 = Major Histocompatibility Complex, Class II, DQ Alpha 1; HLA-DQB1 = Major Histocompatibility Complex, Class II, DQ Beta 1; IL18R1 = Interleukin 18 Receptor 1; IL1RL1 = Interleukin 1 Receptor Like 1; IRF4 = interferon regulatory factor 4; OR = odds ratio.
See this image and copyright information in PMC

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