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Review
. 2023 May;37(5):e22896.
doi: 10.1096/fj.202202166R.

Dendritic spine dynamics in associative memory: A comprehensive review

Hongling Guo  1 , Tahir Ali  1 , Jianyu Que  2 , Yanmei Zhou  3 , Yang Bai  3
Affiliations
Review

Dendritic spine dynamics in associative memory: A comprehensive review

Hongling Guo et al. FASEB J. 2023 May.

Abstract

Associative learning and memory are fundamental behavioral processes through which organisms adapt to complex environments. Associative memory involves long-lasting changes in synaptic plasticity. Dendritic spines are tiny protrusions from the dendritic shaft of principal neurons, providing the structural basis for synaptic plasticity and brain networks in response to external stimuli. Mounting evidence indicates that dendritic spine dynamics are crucial in different associative memory phases, including acquisition, consolidation, and reconsolidation. Causally bridging dendritic spine dynamics and associative memory is still limited by the suitable tools to measure and control spine dynamics in vivo under behaviorally relevant conditions. Here, we review data providing evidence for the remodeling of dendritic spines during associative memory processing and outline open questions.

Keywords: acquisition; associative memory; consolidation; reconsolidation; spine dynamics.

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References

REFERENCES

    1. Nimchinsky EA, Sabatini BL, Svoboda K. Structure and function of dendritic spines. Annu Rev Physiol. 2002;64:313-353.
    1. Yuste R, Bonhoeffer T. Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci. 2001;24:1071-1089.
    1. Segal M. Dendritic spines and long-term plasticity. Nat Rev Neurosci. 2005;6:277-284.
    1. Hering H, Sheng M. Dendritic spines: structure, dynamics and regulation. Nat Rev Neurosci. 2001;2:880-888.
    1. Harris KM, Jensen FE, Tsao B. Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation. J Neurosci. 1992;12:2685-2705.

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