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Editorial
. 2023 Apr 1;34(4):520-523.
doi: 10.1681/ASN.0000000000000086.

Acidosis in CKD May Affect Mineralization of Newly Formed Bone According to HR-pQCT and Quantitative Back Scatter Electron Imaging

Matthew J Williams  1 , Keith A Hruska  1   2
Affiliations
Editorial

Acidosis in CKD May Affect Mineralization of Newly Formed Bone According to HR-pQCT and Quantitative Back Scatter Electron Imaging

Matthew J Williams et al. J Am Soc Nephrol. .
No abstract available

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Figures

Figure 1
Figure 1
Deduced pathogensis of acidosis stimulated ROD. Stage 3b and 4 CKD produce metabolic acidosis. Increased proton levels impair hydroxyl apatite formation on newly formed collagen fibrils in the mineralization fronts of bone formation. This weakens newly formed bone. In addition, proton stimulation of RANKL production in osteoblasts stimulates osteoclastogenesis and NFATc1 stimulation in osteoclasts leading to increased bone turnover. The hypomineralized trabeculae are subject to breaks and resorption decreasing trabecular bone density. The weakened bone structures subjected to weight-bearing result in cortical expansion and fracture risk. NFATc1, nuclear factor of activated T cells.
See this image and copyright information in PMC

Comment on

References

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