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doi: 10.1016/j.ccell.2023.02.020.
Epub 2023 Mar 30.
A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade
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- PMID: 37001525
- DOI: 10.1016/j.ccell.2023.02.020
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A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade
Cancer Cell.
.
Free article
Abstract
Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely understood. In this issue, Pai et al. present a temporally and spatially resolved differentiation map of tumor-directed T cells in patients with lung cancer on PD-1 blockade.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade.Cancer Cell. 2023 Apr 10;41(4):776-790.e7. doi: 10.1016/j.ccell.2023.03.009. Epub 2023 Mar 30. Cancer Cell. 2023. PMID: 37001526 Free PMC article.
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