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Review
. 2023 May;107(3):465-489.
doi: 10.1016/j.mcna.2023.01.008.

Hepatic Manifestations of Systemic Diseases

Humberto C Gonzalez  1 , Stuart C Gordon  2
Affiliations
Review

Hepatic Manifestations of Systemic Diseases

Humberto C Gonzalez et al. Med Clin North Am. 2023 May.

Abstract

In addition to being the primary target of infections such as viral hepatitis, the liver may also be affected by systemic disease. These include bacterial, mycotic, and viral infections, as well as autoimmune and infiltrative diseases. These conditions generally manifest as abnormal liver biochemistries, often with a cholestatic profile, and may present with additional signs/symptoms such as jaundice and fever. A high index of suspicion and familiarity with potential causal entities is necessary to guide appropriate testing, diagnosis, and treatment.

Keywords: Amyloidosis; Brucellosis; Covid-19; Cytomegalovirus (CMV); Epstein-Barr (EBV); Histoplasmosis; Sarcoidosis; Tuberculosis.

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