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. 2023 Apr 24;41(17):2769-2772.
doi: 10.1016/j.vaccine.2023.03.044. Epub 2023 Mar 27.

Comparison of culture-competent virus shedding duration of SARS-CoV-2 Omicron variant in regard to vaccination status: A prospective cohort study

Sung-Woon Kang  1 , Heedo Park  2 , Ji Yeun Kim  1 , Joon-Yong Bae  3 , Man-Seong Park  4 , Sung-Han Kim  5
Affiliations

Comparison of culture-competent virus shedding duration of SARS-CoV-2 Omicron variant in regard to vaccination status: A prospective cohort study

Sung-Woon Kang et al. Vaccine. .

Abstract

Previous studies have shown that fully vaccinated patients with SARS-CoV-2 Delta variants has shorter viable viral shedding period compared to unvaccinated or partially vaccinated patients. However, data about effects of vaccination against the viable viral shedding period in patients with SARS-CoV-2 Omicron variants were limited. We compared the viable viral shedding period of SARS-CoV-2 omicron variant regard to vaccination status. Saliva samples were obtained daily from patients with SARS-CoV-2 Omicron variant, and genomic assessments and virus culture was performed to those samples. We found no difference in viable viral shedding period between fully vaccinated and not or partially vaccinated, nor between 1st boostered vs non-boostered patients with SARS-CoV-2 Omicron variant.

Keywords: Infection dynamics; SARS-CoV-2; Virus shedding.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Comparison of the viral shedding period between fully vaccinated and not or partially vaccinated patients with the omicron variant. (A) Genomic RNA PCR. (B) Subgenomic RNA PCR. (C) Culture-based virus isolation. The red line indicates the delta group, whereas the blue line indicates the omicron group. The P-values in the figures were calculated with the log-rank test.
See this image and copyright information in PMC

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