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Review
. 2023 Apr;40(2):56-65.
doi: 10.1007/s10014-023-00457-6. Epub 2023 Apr 1.

Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas

Yoshihiro Otani  1 , Kaishi Satomi  2 , Yasuki Suruga  3 , Joji Ishida  3 , Kentaro Fujii  3 , Koichi Ichimura  4 , Isao Date  3
Affiliations
Free article
Review

Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas

Yoshihiro Otani et al. Brain Tumor Pathol. 2023 Apr.
Free article

Abstract

Despite the current progress of treatment, pediatric-type diffuse glioma is one of the most lethal primary malignant tumors in the central nervous system (CNS). Since pediatric-type CNS tumors are rare disease entities and highly heterogeneous, the diagnosis is challenging. An accurate diagnosis is essential for the choice of optimal treatment, which leads to precision oncology and improvement of the patient's outcome. Genome-wide DNA methylation profiling recently emerged as one of the most important tools for the diagnosis of CNS tumors, and the utility of this novel assay has been reported in both pediatric and adult patients. In the current World Health Organization classification published in 2021, several new entities are recognized in pediatric-type diffuse gliomas, some of which require methylation profiling. In this review, we investigated the utility of genome-wide DNA methylation profiling in pediatric-type diffuse glioma, as well as issues in the clinical application of this assay. Furthermore, the combination of genome-wide DNA methylation profiling and other comprehensive genomic assays, which may improve diagnostic accuracy and detection of the actionable target, will be discussed.

Keywords: Genome-wide DNA methylation profiling; Pediatric brain tumor; Pediatric-type diffuse glioma.

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References

    1. Bale TA, Rosenblum MK (2022) The 2021 WHO Classification of Tumors of the Central Nervous System: an update on pediatric low-grade gliomas and glioneuronal tumors. Brain Pathol 32(4):e13060 - PubMed - PMC - DOI
    1. Benezech S, Saintigny P, Attignon V et al (2020) Tumor molecular profiling: pediatric results of the ProfiLER Study. JCO Precis Oncol 4:785–795 - PubMed - DOI
    1. Berlanga P, Pierron G, Lacroix L et al (2022) The European MAPPYACTS Trial: precision medicine program in pediatric and adolescent patients with recurrent malignancies. Cancer Discov 12(5):1266–1281 - PubMed - PMC - DOI
    1. Bielle F, Di Stefano AL, Meyronet D et al (2018) Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features. Brain Pathol 28(5):674–683 - PubMed - DOI
    1. Broggi G, Piombino E, Altieri R et al (2022) Glioblastoma, IDH-wild type with FGFR3-TACC3 fusion: when morphology may reliably predict the molecular profile of a tumor. A case report and literature review. Front Neurol 13:823015 - PubMed - PMC - DOI