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Review
. 2023 Jun;59(3):464-472.
doi: 10.1007/s11262-023-01990-4. Epub 2023 Apr 1.

Characterization of Phietavirus Henu 2 in the virome of individuals with acute gastroenteritis

Endrya do Socorro Fôro Ramos  1 , Santana Lobato Bahia  1 , Geovani de Oliveira Ribeiro  1 , Fabiola Villanova  1 , Flávio Augusto de Pádua Milagres  2   3 , Rafael Brustulin  2   3 , Ramendra Pati Pandey  4 , Xutao Deng  5   6 , Eric Delwart  5   6 , Antonio Charlys da Costa  7 , Élcio Leal  8
Affiliations
Review

Characterization of Phietavirus Henu 2 in the virome of individuals with acute gastroenteritis

Endrya do Socorro Fôro Ramos et al. Virus Genes. 2023 Jun.

Abstract

There is a growing interest in phages as potential biotechnological tools in human health owing to the antibacterial activity of these viruses. In this study, we characterized a new member (named PhiV_005_BRA/2016) of the recently identified phage species Phietavirus Henu 2. PhiV_005_BRA/2016 was detected through metagenomic analysis of stool samples of individuals with acute gastroenteritis. PhiV_005_BRA/2016 contains double-stranded linear DNA (dsDNA), it has a genome of 43,513 base pairs (bp), with a high identity score (99%) with phage of the genus Phietavirus, species of Phietavirus Henu 2. Life style prediction indicated that PhiV_005_BRA/2016 is a lysogenic phage whose the main host is methicillin-resistant Staphylococcus aureus (MRSA). Indeed, we found PhiV_005_BRA/2016 partially integrated in the genome of distinct MRSA strains. Our findings highlights the importance of large-scale screening of bacteriophages to better understand the emergence of multi-drug resistant bacterial.

Keywords: Biotechnology; Gastroenteritis; Methicillin-resistant; Phage; Phietavirus; Staphylococcus aureus.

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