Disclosures Dr Tromp is supported by the National University of Singapore Start-up grant, the tier 1 grant from the ministry of education and the CS-IRG New Investigator Grant from the National Medical Research Council; has received consulting or speaker fees from Daiichi-Sankyo, Boehringer Ingelheim, Roche diagnostics and Us2.ai, owns patent US-10702247-B2 unrelated to the present work. Dr. van der Meer received consultancy fees and/or grants from Novartis, Corvidia, Servier, Vifor Pharma, AstraZeneca, Pfizer, Pharmacosmos and Ionis. Dr Lam reports receiving grant support and fees for serving on an advisory board from Boston Scientific and Roche Diagnostics, grant support, fees for serving on an advisory board, and fees for serving on steering committees from Bayer, grant support from Medtronics, grant support, and fees for serving on a steering committee from Vifor Pharma, fees for serving on an advisory board and fees for serving on steering committees from AstraZeneca and Novartis, fees for serving on an advisory board from Amgen, Boehringer Ingelheim, and Abbott Diagnostics, consulting fees from Merck and Stealth BioTherapeutics, fees for serving on a steering committee from Janssen Research and Development, lecture fees and consulting fees from Menarini, and fees for serving on a scientific committee from Corvia Medical and holding a pending patent (PCT/SG2016/050217) on a method regarding diagnosis and prognosis of chronic heart failure. All other authors have nothing to disclose.