Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 16:14:1022579.
doi: 10.3389/fphar.2023.1022579. eCollection 2023.

Chemoprophylaxis for the prevention of tuberculosis in kidney transplant recipients: A systematic review and meta-analysis

Zhihui Yuan  1 , Sheng Chao  1 , Yuan Xu  1 , Yulin Niu  1
Affiliations

Chemoprophylaxis for the prevention of tuberculosis in kidney transplant recipients: A systematic review and meta-analysis

Zhihui Yuan et al. Front Pharmacol. .

Abstract

Background: A systematic review and meta-analysis was performed to investigate the efficacy and safety of isoniazid (INH) prophylaxis to prevent tuberculosis (TB) infection in kidney transplant recipients (KTRs). Methods: Web of Science, SCOPUS, and PubMed were searched to identify relevant studies that compared the effects among patients who received INH prophylaxis after transplantation. Results: A total of 13 studies (involving 6,547 KTRs) were included in our analysis. We found that the risk of active TB infection (RR: 0.35, 95%CI 0.27-0.45, p < 0.01) for KTRs was lower in the INH treatment group than in those without prophylaxis. However, there was no significant difference between the two groups in mortality (RR: 0.93, 95%CI 0.67-1.28, p = 0.64), acute rejection (RR: 0.82, 95%CI 0.44-1.51, p = 0.52), and hepatotoxicity (RR: 1.25, 95%CI 0.94-1.65, p = 0.12). Conclusion: Isoniazid prophylaxis is a safe and effective for KTRs on reactivation of latent TB infection.

Keywords: analysis; isoniazid; kidney transplant; meta; prophylaxis; tuberculosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Procedure for search and selection of studies included in the systematic review and meta-analysis.
FIGURE 2
FIGURE 2
Risk of bias for included studies.
FIGURE 3
FIGURE 3
Forest plot for outcomes of active TB comparing isoniazid versus no treatment.
FIGURE 4
FIGURE 4
Forest plot for outcomes of all-cause mortality comparing isoniazid versus no treatment.
FIGURE 5
FIGURE 5
Forest plot for outcomes of acute rejection comparing isoniazid versus no treatment.
FIGURE 6
FIGURE 6
Sensitivity analyses for acute rejection.
FIGURE 7
FIGURE 7
Forest plot for outcomes of hepatotoxicity comparing isoniazid versus no treatment.
See this image and copyright information in PMC

References

    1. Abad C. L. R., Razonable R. R. (2018). Mycobacterium tuberculosis after solid organ transplantation: A review of more than 2000 cases. Clin. Transpl. 32 (6), e13259. 10.1111/ctr.13259 - DOI - PubMed
    1. Adamu B., Abdu A., Abba A. A., Borodo M. M., Tleyjeh I. M. (2014). Antibiotic prophylaxis for preventing post solid organ transplant tuberculosis. Cochrane Database Syst. Rev. 2014(3), Cd008597. 10.1002/14651858.CD008597.pub2 - DOI - PMC - PubMed
    1. Agarwal S. K., Gupta S., Dash S. C., Bhowmik D., Tiwari S. C. (2004). Prospective randomised trial of isoniazid prophylaxis in renal transplant recipient. Int. Urol. Nephrol. 36 (3), 425–431. 10.1007/s11255-004-6251-6 - DOI - PubMed
    1. Aguado J. M., Torre-Cisneros J., Fortún J., Benito N., Meije Y., Doblas A., et al. (2009). Tuberculosis in solid-organ transplant recipients: Consensus statement of the group for the study of infection in transplant recipients (GESITRA) of the Spanish society of infectious diseases and clinical microbiology. Clin. Infect. Dis. 48 (9), 1276–1284. 10.1086/597590 - DOI - PubMed
    1. Antony S. J., Ynares C., Dummer J. S. (1997). Isoniazid hepatotoxicity in renal transplant recipients. Clin. Transpl. 11 (1), 34–37. - PubMed

Publication types

LinkOut - more resources