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Review
. 2023 Mar 16:14:1129817.
doi: 10.3389/fphar.2023.1129817. eCollection 2023.

The protective effects of baicalin for respiratory diseases: an update and future perspectives

Siyu Song  1 , Lu Ding  1 , Guangwen Liu  2 , Tian Chen  3 , Meiru Zhao  3 , Xueyan Li  3 , Min Li  3 , Hongyu Qi  1 , Jinjin Chen  1 , Ziyuan Wang  4 , Ying Wang  4 , Jing Ma  4 , Qi Wang  3 , Xiangyan Li  1 , Zeyu Wang  1
Affiliations
Review

The protective effects of baicalin for respiratory diseases: an update and future perspectives

Siyu Song et al. Front Pharmacol. .

Abstract

Background: Respiratory diseases are common and frequent diseases. Due to the high pathogenicity and side effects of respiratory diseases, the discovery of new strategies for drug treatment is a hot area of research. Scutellaria baicalensis Georgi (SBG) has been used as a medicinal herb in China for over 2000 years. Baicalin (BA) is a flavonoid active ingredient extracted from SBG that BA has been found to exert various pharmacological effects against respiratory diseases. However, there is no comprehensive review of the mechanism of the effects of BA in treating respiratory diseases. This review aims to summarize the current pharmacokinetics of BA, baicalin-loaded nano-delivery system, and its molecular mechanisms and therapeutical effects for treating respiratory diseases. Method: This review reviewed databases such as PubMed, NCBI, and Web of Science from their inception to 13 December 2022, in which literature was related to "baicalin", "Scutellaria baicalensis Georgi", "COVID-19", "acute lung injury", "pulmonary arterial hypertension", "asthma", "chronic obstructive pulmonary disease", "pulmonary fibrosis", "lung cancer", "pharmacokinetics", "liposomes", "nano-emulsions", "micelles", "phospholipid complexes", "solid dispersions", "inclusion complexes", and other terms. Result: The pharmacokinetics of BA involves mainly gastrointestinal hydrolysis, the enteroglycoside cycle, multiple metabolic pathways, and excretion in bile and urine. Due to the poor bioavailability and solubility of BA, liposomes, nano-emulsions, micelles, phospholipid complexes, solid dispersions, and inclusion complexes of BA have been developed to improve its bioavailability, lung targeting, and solubility. BA exerts potent effects mainly by mediating upstream oxidative stress, inflammation, apoptosis, and immune response pathways. It regulates are the NF-κB, PI3K/AKT, TGF-β/Smad, Nrf2/HO-1, and ERK/GSK3β pathways. Conclusion: This review presents comprehensive information on BA about pharmacokinetics, baicalin-loaded nano-delivery system, and its therapeutic effects and potential pharmacological mechanisms in respiratory diseases. The available studies suggest that BA has excellent possible treatment of respiratory diseases and is worthy of further investigation and development.

Keywords: baicalin; baicalin-loaded nano-delivery system; molecular mechanisms; pharmacokinetics; pharmacological action; respiratory diseases.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The therapeutic mechanism of baicalin on coronary viral disease-2019 (graphics courtesy of freepik.com).
FIGURE 2
FIGURE 2
A summary of the main pharmacological effects of baicalin and its mechanisms involved in respiratory diseases (graphics courtesy of freepik.com).
FIGURE 3
FIGURE 3
The therapeutic effects of baicalin on immune modulation on respiratory disease (graphics courtesy of freepik.com).
FIGURE 4
FIGURE 4
The therapeutic mechanism and critical pathways of baicalin against respiratory diseases (graphics courtesy of figdraw.com/static/index.html#/ and freepik.com).
See this image and copyright information in PMC

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References

    1. Akao T., Kawabata K., Yanagisawa E., Ishihara K., Mizuhara Y., Wakui Y., et al. (2000). Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J. Pharm. Pharmacol. 52 (12), 1563–1568. 10.1211/0022357001777621 - DOI - PubMed
    1. Akao T., Sato K., He J. X., Ma C. M., Hattori M. (2013). Baicalein 6-O-β-D-glucopyranuronoside is a main metabolite in the plasma after oral administration of baicalin, a flavone glucuronide of scutellariae radix, to rats. Biol. Pharm. Bull. 36 (5), 748–753. 10.1248/bpb.b12-00850 - DOI - PubMed
    1. Allen T. C., Kurdowska A. (2014). Interleukin 8 and acute lung injury. Arch. Pathol. Lab. Med. 138 (2), 266–269. 10.5858/arpa.2013-0182-RA - DOI - PubMed
    1. Apps M. G., Choi E. H., Wheate N. J. (2015). The state-of-play and future of platinum drugs. Endocr. Relat. Cancer 22 (4), R219–R233. 10.1530/ERC-15-0237 - DOI - PubMed
    1. Banno A., Reddy A. T., Lakshmi S. P., Reddy R. C. (2020). Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clin. Sci. (Lond) 134 (9), 1063–1079. 10.1042/CS20191309 - DOI - PubMed