Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar 16:11:1152217.
doi: 10.3389/fchem.2023.1152217. eCollection 2023.

Brief review: Applications of nanocomposite in electrochemical sensor and drugs delivery

Zia Ul Haq Khan  1 , Taj Malook Khan  2   3 , Amjad Khan  4 , Noor Samad Shah  1 , Nawshad Muhammad  5 , Kamran Tahir  6 , Jibran Iqbal  7 , Abdur Rahim  8 , Syed Khasim  9   10 , Iftikhar Ahmad  1 , Khadija Shabbir  1 , Noor Shad Gul  2   3 , Jianbo Wu  2   3
Affiliations
Review

Brief review: Applications of nanocomposite in electrochemical sensor and drugs delivery

Zia Ul Haq Khan et al. Front Chem. .

Abstract

The recent advancement of nanoparticles (NPs) holds significant potential for treating various ailments. NPs are employed as drug carriers for diseases like cancer because of their small size and increased stability. In addition, they have several desirable properties that make them ideal for treating bone cancer, including high stability, specificity, higher sensitivity, and efficacy. Furthermore, they might be taken into account to permit the precise drug release from the matrix. Drug delivery systems for cancer treatment have progressed to include nanocomposites, metallic NPs, dendrimers, and liposomes. Materials' mechanical strength, hardness, electrical and thermal conductivity, and electrochemical sensors are significantly improved using nanoparticles (NPs). New sensing devices, drug delivery systems, electrochemical sensors, and biosensors can all benefit considerably from the NPs' exceptional physical and chemical capabilities. Nanotechnology is discussed in this article from a variety of angles, including its recent applications in the medical sciences for the effective treatment of bone cancers and its potential as a promising option for treating other complex health anomalies via the use of anti-tumour therapy, radiotherapy, the delivery of proteins, antibiotics, and vaccines, and other methods. This also brings to light the role that model simulations can play in diagnosing and treating bone cancer, an area where Nanomedicine has recently been formulated. There has been a recent uptick in using nanotechnology to treat conditions affecting the skeleton. Consequently, it will pave the door for more effective utilization of cutting-edge technology, including electrochemical sensors and biosensors, and improved therapeutic outcomes.

Keywords: diagnosis; nano-formulations; nano-systems; nanotechnology; targeted drug delivery; treatment of disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Various nanomaterials used in cancer therapy, their critical physical features, and the surface chemistry needed to transport drugs are depicted in this diagram. [Reprinted with permission from Nanomaterial MDPI, at2020].
FIGURE 2
FIGURE 2
Nanoparticle usage for diagnosis and therapy of cancer.
FIGURE 3
FIGURE 3
Different nanoparticles for diagnosis of osteosarcoma (OSA). [Reprinted with permission from Biosensors, MDPI, at2021].
FIGURE 4
FIGURE 4
A biodegradable (polymer-based) carrier delivers NPs locally in bone. Notes: A schematic diagram shows an ideal NP capable of conveying a range of cargos, including molecules with affinity for bone tissue or cells, such as BPs, siRNA for gene therapy, and medications for bone diseases. [Reprinted with permission from International Journal of Nanomedicine at 2013].
FIGURE 5
FIGURE 5
Porous mesoporous bioactive glass scaffolds with large pores (several hundred micrometers, left) and well-ordered mesoporous channel structures (5 nm, right). [Reprinted with permission from International Journal of Nanomedicine @June 2013].
FIGURE 6
FIGURE 6
Overview of nanoparticle applications in bone.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Abdal-Hay A., Sheikh F. A., Biointerfaces S. B. (2013). Air jet spinning of hydroxyapatite/poly (lactic acid) hybrid nanocomposite membrane mats for bone tissue engineering. Colloids Surfaces B Biointerfaces. 102, 635–643. 10.1016/j.colsurfb.2012.09.017 - DOI - PubMed
    1. Abrams D., Huang Y., Mcquarrie S., Roa W., Chen H., Löbenberg R., et al. (2006). Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells. - PubMed
    1. Abunahla H., Mohammad B., Alazzam A., Jaoude M. A., Al-Qutayri M., Abdul Hadi S., et al. (2019). MOMSense: Metal-oxide-metal elementary glucose sensor. Sci. Rep. 9, 5524. 10.1038/s41598-019-41892-w - DOI - PMC - PubMed
    1. Adeel M., Duzagac F., Canzonieri V., Rizzolio F. (2020). Self-therapeutic nanomaterials for cancer therapy: A review. ACS Appl. Nano Mater. 3, 4962–4971. 10.1021/acsanm.0c00762 - DOI
    1. Ahmad A., Wei Y., Syed F., Imran M., Khan Z. U. H., Tahir K., et al. (2015). Size dependent catalytic activities of green synthesized gold nanoparticles and electro-catalytic oxidation of catechol on gold nanoparticles modified electrode. RSC Adv. 5, 99364–99377. 10.1039/c5ra20096b - DOI

LinkOut - more resources