Glial cells of an insect ganglion

Abstract

The rapid development of the study of insect neurobiology, which is currently occurring principally because individual neurons can be re-identified and because their activities can be recorded in situ and related to behavior, is generating a demand for more knowledge concerning insect glial cells and their functional relationships with neurons. This study examines the ultrastructure of glial cells in locust metathoracic ganglia in relation to general locale within the ganglion and also to specific identified neurons and neuron types. Seven major types of glial cell form are recognized, with subdivisions, requiring a new scheme for classification. Glial invaginations into neurons are of four different kinds: regular, chunky, filigree, and ridge (found only at axon hillocks). They also range from only intrusive to fully reciprocal. In addition, some neurons make projections of various lengths into surrounding glia and between neighboring neuron somata, and some glia make long, branched projections into other glial cells. The differences show that insect glial cells develop highly specific functional specializations; they may not be interchangeable. The complexity and intimacy of relationships of glia with neurons suggest that some glial cells may have roles other than that of nursemaids, possibly in modulation of behavior-determining neural activity, and in learning and other adaptive acts.