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Review
. 2023;18(1):61-66.
doi: 10.5114/pg.2021.112683. Epub 2022 Jan 18.

Gastrointestinal symptoms in COVID-19

Konrad Lewandowski  1 , Magdalena Kaniewska  1 , Mariusz Rosołowski  2   3 , Grażyna Rydzewska  1   4
Affiliations
Review

Gastrointestinal symptoms in COVID-19

Konrad Lewandowski et al. Prz Gastroenterol. 2023.

Abstract

SARS-CoV-2 infection manifests mainly by involving the respiratory system. Due to the presence of abdominal symptoms, the digestive system is clearly involved in the expression, transmission, and possible pathogenesis of COVID-19. There are many theories regarding the development of abdominal symptoms, including angiotensin 2 receptor, cytokine storm, and disturbances of the intestinal microbiome. This paper provides an overview of the most important meta-analyses and publications on gastrointestinal symptoms and the gut microbiome in COVID-19.

Keywords: COVID-19; SARS-CoV-2; gastrointestinal symptoms; gut microbiota.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Xiao F, Tang M, Zheng X, et al. . Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology 2020; 158: 1831-3. - PMC - PubMed
    1. Du M, Cai G, Chen F, et al. . Multiomics evaluation of gastrointestinal and other clinical characteristics of SARS-CoV-2 and COVID-19. Gastroenterology 2020; 158: 2298-3230. - PMC - PubMed
    1. ACE2 angiotensin I converting enzyme 2 [Homo sapiens (human)]. Gene ID: 59272. Available from: https://www.ncbi.nlm.nih.gov/gene/59272. Accessed May 9, 2020.
    1. Han C, Duan C, Zhang S, et al. . Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes. Am J Gastroenterol 2020; 115: 916-23. - PMC - PubMed
    1. Wu Y, Guo C, Tang L, et al. . Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterol Hepatol 2020; 5: 434-5. - PMC - PubMed