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Review
. 2023 Mar 27:18:1537-1560.
doi: 10.2147/IJN.S395438. eCollection 2023.

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Mengqian Liu  1 , Xuerong Wei  1 , Zijun Zheng  1 , Yicheng Li  1 , Mengyao Li  1 , Jiabao Lin  1 , Lei Yang  1
Affiliations
Review

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Mengqian Liu et al. Int J Nanomedicine. .

Abstract

Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem and burden on the clinical obligation for high amputation rates. Based on the features of wound microenvironment, biomaterials loading specific drugs can benefit diabetic wound treatment. Drug delivery systems (DDSs) can carry diverse functional substances to the wound site. Nano-drug delivery systems (NDDSs), benefiting from their features related to nano size, overcome limitations of conventional DDSs application and are considered as a developing process in the wound treatment field. Recently, a number of finely designed nanocarriers efficiently loading various substances (bioactive and non-bioactive factors) have emerged to circumvent constraints faced by traditional DDSs. This review describes various recent advances of nano-drug delivery systems involved in mitigating diabetes mellitus-based non-healing wounds.

Keywords: diabetic wound healing; drug delivery system; nanoparticles; nanotechnology.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The physiological process of normal wounds. (figure was created with BioRender.com).
Figure 2
Figure 2
The pathophysiological processes of wound healing and diabetic wound healing. (figure was created with BioRender.com).
Figure 3
Figure 3
Schematic representation of nano-drug delivery system used for diabetic wound healing: Liposomes, Polymeric nanoparticles, inorganic nanoparticles, lipid nanoparticles, nanofibers, nano-hydrogels. (figure was created with BioRender.com).
Figure 4
Figure 4
Schematic diagram of wound healing by nano-insulin formulation (IAgNPs). IAgNPs accelerated the wound healing in diabetic conditions by inhibiting pro-inflammatory cytokines and activating anti-inflammatory cytokines.
Figure 5
Figure 5
Accelerate the healing wound following treatment using functionally active insulin released from insulin-loaded nanofibrous scaffolds.
Figure 6
Figure 6
The schematic diagram of the method of making exo@H and the process that exosomes were applied to the wound area and promoted wound healing.
See this image and copyright information in PMC

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