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. 2023 Mar 26:14:27534030231161784.
doi: 10.1177/27534030231161784. eCollection 2023 Jan-Dec.

Epinephrine Administered in Anaphylaxis: The Evolution of 0.3 mg Dosage

Peyton Coady  1 , Kenneth L Dretchen  1 , Michael Mesa  1
Affiliations

Epinephrine Administered in Anaphylaxis: The Evolution of 0.3 mg Dosage

Peyton Coady et al. Ther Adv Allergy Rhinol. .

Abstract

Background: Despite epinephrine's historical use for over a century and Food and Drug Administration (FDA) approval for EpiPen's use in 1987 to treat anaphylaxis, little information exists regarding selection of the 0.3 mg adult dose. A review of literature was conducted to provide a historical retrospective regarding the evolution of the dosage selected for today's EpiPen. The first adrenal gland extract, isolation of the epinephrine active ingredient, observation of physiological effect, selection of the intramuscular route for administration, the dosage range recommended by independent physicians based on their clinical observations and selection of the ultimate standardized dosage are profiled.

Conclusion: This retrospective review illustrates the drug development process prior to the rigors required for today's clinical trials and provides clinical evidence supporting the dose in EpiPen and other similar life-saving epinephrine products.

Keywords: adrenal extract; adrenaline; anaphylaxis; asthma; dosage; epiPen; epinephrine; hay fever; hormone; intramuscular.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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