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Review
. 2023 Mar 4;9(1):100320.
doi: 10.1016/j.jve.2023.100320. eCollection 2023 Mar.

Influencing factors and adverse outcomes of virologic rebound states in anti-retroviral-treated individuals with HIV infection

Defu Yuan  1 , Mingma Li  1 , Ying Zhou  2 , Lingen Shi  2 , Jing Lu  2 , Gengfeng Fu  2 , Bei Wang  1
Affiliations
Review

Influencing factors and adverse outcomes of virologic rebound states in anti-retroviral-treated individuals with HIV infection

Defu Yuan et al. J Virus Erad. .

Abstract

Antiretroviral therapy (ART) aims to inhibit HIV replication, decrease CD4 T cell loss, and immune function recovery in order to reduce the morbidity and mortality associated with the infection. Treatment should also, improve quality of life and control HIV spread. However, incomplete viral suppression still occurs during ART. Viral suppression and virological failure (VF) thresholds vary between studies in terms of virological rebound (VR) states using different detection thresholds. Further understanding of influencing factors and adverse outcomes in various VR states should provide important guidance for HIV treatment.

Keywords: Antiretroviral therapy; Blips; HIV/AIDS; Low-level viremia; Viral load; Virological failure; Virological rebound.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Publication yearly distribution of virologic rebound-related articles.
Fig. 2
Fig. 2
Top ten journals with virological rebound-related articles.
Fig. 3
Fig. 3
Keyword co-occurrence and cluster analysis .
See this image and copyright information in PMC

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