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Clinical Trial
. 2023 Mar 16:36:10951.
doi: 10.3389/ti.2023.10951. eCollection 2023.

Tremor, Daily Functioning, and Health-Related Quality of Life in Solid Organ Transplant Recipients

Niels L Riemersma  1 , Daan Kremer  1 , Tim J Knobbe  1 , C Tji Gan  1   2 , Svea Nolte  1 , António W Gomes-Neto  1 , Hans Blokzijl  3 , Vincent E de Meijer  4 , Kevin Damman  5 , Michele F Eisenga  1 , Gea Drost  6 , Jan Willem J Elting  6 , Daan J Touw  7   8 , Stefan P Berger  1 , Stephan J L Bakker  1 , A M Madelein van der Stouwe  6   9 ; Transplantlines Investigators
Collaborators, Affiliations
Clinical Trial

Tremor, Daily Functioning, and Health-Related Quality of Life in Solid Organ Transplant Recipients

Niels L Riemersma et al. Transpl Int. .

Abstract

Solid organ transplant recipients (SOTR) frequently report tremor. Data concerning tremor-related impairment and its potential impact on health-related quality of life (HRQoL) are lacking. This cross-sectional study assesses impact of tremor on activities of daily living and HRQoL using validated questionnaires among SOTR enrolled in the TransplantLines Biobank and Cohort Study. We included 689 SOTR (38.5% female, mean [±SD] age 58 [±14] years) at median [interquartile range] 3 [1-9] years after transplantation, of which 287 (41.7%) reported mild or severe tremor. In multinomial logistic regression analyses, whole blood tacrolimus trough concentration was an independent determinant of mild tremor (OR per µg/L increase: 1.11, 95% CI: 1.02 to 1.21, p = 0.019). Furthermore, in linear regression analyses, severe tremor was strongly and independently associated with lower physical and mental HRQoL (β = -16.10, 95% CI: -22.23 to -9.98, p < 0.001 and β = -12.68, 95% CI: -18.23 to -7.14, p < 0.001 resp.). SOTR frequently report tremor-related impairment of activities of daily living. Tacrolimus trough concentrations appeared as a main determinant of tremor among SOTR. The strong and independent association of tremor-related impairment with lower HRQoL warrants further studies into the effects of tacrolimus on tremor. Clinical Trial Registration: ClinicalTrials.gov, Identifier NCT03272841.

Keywords: ADL impairment; calcineurin inhibitors; health-related quality of life; solid organ transplant recipient; tremor.

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Conflict of interest statement

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Bar chart of TRS-C total score in 689 SOTR. (B) Pie-chart of tremor severity in 689 SOTR.
FIGURE 2
FIGURE 2
Bar charts of tremor severity group distribution per transplant type.
FIGURE 3
FIGURE 3
Boxplots of PCS, and MCS for HRQoL in 689 SOTR (mild and severe tremor present in 206 (29.9%) and 81 (11.8%) SOTR, respectively). The PCS, and MCS differed significantly between groups as calculated using Analyses of Variance (p < 0.001; p < 0.001, resp.).
See this image and copyright information in PMC

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