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. 2023 Jun:33:100655.
doi: 10.1016/j.cophys.2023.100655. Epub 2023 Mar 2.

VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA

Xi Wang  1 , Corbin A Shields  2 , Ubong Ekperikpe  1 , Lorena M Amaral  1 , Jan Michael Williams  1 , Denise C Cornelius  1   2
Affiliations

VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA

Xi Wang et al. Curr Opin Physiol. 2023 Jun.

Abstract

Preeclampsia (PE) is a multisystem obstetric disorder that affects 2-10% of pregnancies worldwide and it is a leading cause of maternal and fetal morbidity and mortality. The etiology of PE development is not clearly delineated, but since delivery of the fetus and placenta often leads to symptom resolution in the most cases of PE, it is hypothesized that the placenta is the inciting factor of the disease. Current management strategies for PE focus on treating the maternal symptoms to stabilize the mother in an attempt to prolong the pregnancy. However, the efficacy of this management strategy is limited. Therefore, identification of novel therapeutic targets and strategies is needed. Here, we provide a comprehensive overview of the current state of knowledge regarding mechanisms of vascular and renal pathophysiology during PE and discuss potential therapeutic targets directed at improving maternal vascular and renal function.

Keywords: Preeclampsia; renal dysfunction; vascular dysfunction.

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