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Review
. 2023 Mar 16:15:1130253.
doi: 10.3389/fnagi.2023.1130253. eCollection 2023.

Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Juan Huang  1   2   3 , Nanqu Huang  4 , Qianhua Mao  2 , Jingshan Shi  2 , Yu Qiu  1
Affiliations
Review

Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Juan Huang et al. Front Aging Neurosci. .

Abstract

There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), and the link between the two is often referred to as type 3 diabetes mellitus (T3DM). Many natural bioactive compounds have shown the potential to treat AD and diabetes. We mainly review the polyphenols represented by resveratrol (RES) and proanthocyanidins (PCs) and alkaloids represented by berberine (BBR) and Dendrobium nobile Lindl. alkaloids (DNLA) from the perspective of T3DM to review the neuroprotective effects and molecular mechanisms of natural compounds in AD.

Keywords: Alzheimer's disease; alkaloids; antidiabetic medication; natural bioactive compounds; polyphenols; traditional Chinese medicines; type 2 diabetes mellitus; type 3 diabetes mellitus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
A simplified schematic diagram representing natural bioactive compounds in AD. From the perspective of T3DM. Grape—RES, blueberry—PCs, Coptis chinensis—BBR, and Dendrobium nobile Lindl.—DNLA.
Figure 2
Figure 2
A simplified schematic diagram representing natural bioactive compounds in AD. Although there are some positive pieces of evidence, there are still many opportunities and challenges, and there are still many issues worthy of discussion.
See this image and copyright information in PMC

References

    1. Akbar M., Shabbir A., Rehman K., Akash M. S. H., Shah M. A. (2021). Neuroprotective potential of berberine in modulating Alzheimer's disease via multiple signaling pathways. J. Food Biochem. 45, e13936. 10.1111/jfbc.13936 - DOI - PubMed
    1. Akimoto H., Negishi A., Oshima S., Wakiyama H., Okita M., Horii N., et al. (2020). Antidiabetic drugs for the risk of Alzheimer disease in patients with type 2 DM using FAERS. Am. J. Alzheimers Dis. Other Demen. 35, 1533317519899546. 10.1177/1533317519899546 - DOI - PMC - PubMed
    1. Alzheimer's Disease International (2019). World Alzheimer Report 2019: Attitudes to Dementia [Online]. Available online at: https://www.alz.co.uk/research/world-report-2019 (accessed September 20, 2019).
    1. Asadi S., Moradi M. N., Khyripour N., Goodarzi M. T., Mahmoodi M. (2017). Resveratrol attenuates copper and zinc homeostasis and ameliorates oxidative stress in type 2 diabetic rats. Biol. Trace Elem. Res. 177, 132–138. 10.1007/s12011-016-0861-6 - DOI - PubMed
    1. Bhatt J. K., Thomas S., Nanjan M. J. (2012). Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr. Res. 32, 537–541. 10.1016/j.nutres.2012.06.003 - DOI - PubMed

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