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. 2023 Mar;8(2):105-113.
doi: 10.14744/eej.2022.83097.

Pharmacological Management of Anxiety on Pain Occurrence During Root Canal Treatment: A Systematic Review

Isadora Ames Silva  1 , Charles André Dall Agnol Júnior  1 , Theodoro Weissheimer  1 , Marcus Vinicius Reis So  1 , Ricardo Abreu Da Rosa  1
Affiliations

Pharmacological Management of Anxiety on Pain Occurrence During Root Canal Treatment: A Systematic Review

Isadora Ames Silva et al. Eur Endod J. 2023 Mar.

Abstract

Objective: To answer the question: 'Does the pharmacological management of dental anxiety influence pain occurrence during root canal treatment?'

Methods: Searches on MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, EMBASE and Open Grey were conducted until September 02, 2022. Only randomised clinical trials were included. The Cochrane risk of bias tool for randomized trials (RoB 2) was used. The overall quality of evidence was assessed through the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool.

Results: Initial screening resulted in 811 studies. Three hundred seventy-three were excluded for being duplicates. Of 438 eligible papers, ten studies met the inclusion criteria and were selected for full-text reading. Four studies were included in the final analysis. Three studies had a low risk of bias, and one was a high risk. GRADE demonstrated a low quality of evidence.

Conclusion: There is insufficient evidence to determine whether the pharmacological control of anxiety can influence intraoperative pain occurrence. (EEJ-2022-08-096).

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Conflict of interest statement

The authors deny any conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram representing the systematic review process PRISMA: Preferred Reporting Items for Systematic Review and Meta-Analysis
Figure 2
Figure 2
Quality assessment of the randomized clinical trials according to Cochrane Collaboration common scheme for bias and RoB 2 tool
See this image and copyright information in PMC

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