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. 2023 Apr 18;329(15):1308-1309.
doi: 10.1001/jama.2023.5076.

Antiretroviral Treatment of HIV/AIDS During Pregnancy

Ahizechukwu C Eke  1   2 , Shahin Lockman  3   4   5 , Lynne M Mofenson  6
Affiliations

Antiretroviral Treatment of HIV/AIDS During Pregnancy

Ahizechukwu C Eke et al. JAMA. .
No abstract available

Plain language summary

This Insights in the Women’s Health series describes the availability, timing, and risks of antiretroviral therapy (ART) in pregnant individuals who have HIV infection.

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Conflict of interest statement

Dr Mofenson serves as a paid consultant to the World Health Organization on issues related to antiretroviral drugs in pregnancy, and her employer has received funding from ViiV for a pilot birth outcomes surveillance project in Eswatini. No other disclosures were reported.

References

    1. Sibiude J, Le Chenadec J, Mandelbrot L, et al. Update of perinatal HIV-1 transmission in France: zero transmission for 5482 mothers on continuous ART from conception and with undetectable viral load at delivery. Clin Infect Dis. 2022;76(3):e590–e598. doi:10.1093/cid/ciac703 - DOI - PubMed
    1. Flynn PM, Taha TE, Cababasay M, et al. PROMISE Study Team. Prevention of HIV-1 transmission through breastfeeding: efficacy and safety of maternal antiretroviral therapy versus infant nevirapine prophylaxis for the duration of breastfeeding in HIV-1-infected women with high CD4 cell count (IMPAACT PROMISE): a randomized, open-label clinical trial. J Acquir Immune Defic Syndr. 2018;77(4):383–392. doi:10.1097/QAI.0000000000001612 - DOI - PMC - PubMed
    1. Colbers A, Mirochnick M, Schalkwijk S, et al. Importance of prospective studies in pregnant and breastfeeding women living with human immunodeficiency virus. Clin Infect Dis. 2019;69(7):1254–1258. doi:10.1093/cid/ciz121 - DOI - PMC - PubMed
    1. Boyd SD, Sampson MR, Viswanathan P, et al. Cobicistat-containing antiretroviral regimens are not recommended during pregnancy. AIDS. 2019;33(6):1089–1093. doi:10.1097/QAD.0000000000002163 - DOI - PubMed
    1. Gandhi RT, Bedimo R, Hoy JF, et al. Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the International Antiviral Society-USA Panel. JAMA. 2023;329(1):63–84. doi:10.1001/jama.2022.22246 - DOI - PubMed

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