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Comment
. 2023 Jul;33(7):489-490.
doi: 10.1038/s41422-023-00799-y.

Transgenerational inheritance of engineered cytosine methylation in mice

Maximilian M L Knott  1 , Oded Rechavi  2
Affiliations
Comment

Transgenerational inheritance of engineered cytosine methylation in mice

Maximilian M L Knott et al. Cell Res. 2023 Jul.
No abstract available

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Figures

Fig. 1
Fig. 1. Engineered cytosine methylation is inherited in mice.
a In vitro methylation of CGIs by insertion and subsequent removal of a CpG-free stretch of DNA. b Generation and breeding scheme of mice harboring methylated CGIs in promoter regions. c Methylation dynamics in high- and low-methylated CGIs throughout development.
See this image and copyright information in PMC

Comment on

References

    1. Klemm SL, Shipony Z, Greenleaf WJ. Nat. Rev. Genet. 2019;20:207–220. doi: 10.1038/s41576-018-0089-8. - DOI - PubMed
    1. Miska EA, Ferguson-Smith AC. Science. 2016;354:59–63. doi: 10.1126/science.aaf4945. - DOI - PubMed
    1. He PC, He C. EMBO J. 2021;40:e105977. doi: 10.15252/embj.2020105977. - DOI - PMC - PubMed
    1. Greenberg MVC, Bourc’his D. Nat. Rev. Mol. Cell Biol. 2019;20:590–607. doi: 10.1038/s41580-019-0159-6. - DOI - PubMed
    1. Chen Z, Zhang Y. Annu. Rev. Biochem. 2020;89:135–158. doi: 10.1146/annurev-biochem-103019-102815. - DOI - PubMed