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Review
. 2023 Jul;19(5):1307-1327.
doi: 10.1007/s12015-023-10534-0. Epub 2023 Apr 4.

Regenerative Potential of Human Breast Milk: A Natural Reservoir of Nutrients, Bioactive Components and Stem cells

Pooja Kumari  1 , Aayushi Raval  1 , Pranav Rana  1 , Sanjeev Kumar Mahto  2
Affiliations
Review

Regenerative Potential of Human Breast Milk: A Natural Reservoir of Nutrients, Bioactive Components and Stem cells

Pooja Kumari et al. Stem Cell Rev Rep. 2023 Jul.

Abstract

Human milk is a complex fluid that contains carbohydrates, lipids, proteins, and other bioactive molecules (immunoglobulins, lactoferrin, human milk oligosaccharides, lysozyme, leukocytes, cytokines, hormones, and microbiome) which provide nutritional, immunological, and developmental benefits to the infant. In addition to their involvement in the development, these bioactive compounds have a key role in anti-oncogenicity, neuro-cognitive development, cellular communication, and differentiation. As a result of technological advancements, it has been discovered that human breast milk contains cells that display many of the characteristics of stem cells with multilineage differentiation potentials. Do these cells have any specific properties or roles? Research efforts on breast milk cells have been mainly focused on leukocytes based on their immunological perspective in the early postpartum period. This review summarizes the nutritional components in human milk, i.e., the macro and micronutrients required for the growth and development of infants. Further, it discusses the research work reported concerning the purification, propagation, and differentiation of breast milk progenitor cells and highlights the advancements made in this newly emerging field of stem cell biology and regenerative medicine.

Keywords: Cellular and non-cellular components; Human breast milk-derived cells; Markers; Multilineage differentiation; Multipotent stem cells; Regenerative medicine.

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References

    1. Jenness, R. (1979). The composition of human milk. Seminars in Perinatology, 3(3), 225–239. - PubMed
    1. Kaingade, P., Somasundaram, I., Nikam, A., Behera, P., Kulkarni, S., & Patel, J. (2017). Breast milk cell components and its beneficial effects on neonates: Need for breast milk cell banking. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM), 6(1), e060115–e060115. https://doi.org/10.7363/060115 - DOI
    1. Hassiotou, F., & Geddes, D. (2013). Anatomy of the human mammary gland: Current status of knowledge. Clinical Anatomy (New York, N.Y.), 26(1), 29–48. https://doi.org/10.1002/ca.22165
    1. Key, T. J., Verkasalo, P. K., & Banks, E. (2001). Epidemiology of breast cancer. The Lancet. Oncology, 2(3), 133–140. https://doi.org/10.1016/S1470-2045(00)00254-0 - DOI - PubMed
    1. Patki, S., Kadam, S., Chandra, V., & Bhonde, R. (2010). Human breast milk is a rich source of multipotent mesenchymal stem cells. Human Cell, 23(2), 35–40. https://doi.org/10.1111/j.1749-0774.2010.00083.x - DOI - PubMed

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