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Review
. 2023 Mar 27:16:1405-1418.
doi: 10.2147/JIR.S396604. eCollection 2023.

MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

Bo Yu #  1 , Yalong Zhang #  1 , Tianyu Wang  1 , Jiayu Guo  1 , Chenyang Kong  1 , Zhongbao Chen  1 , Xiaoxiong Ma  1 , Tao Qiu  1
Affiliations
Review

MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

Bo Yu et al. J Inflamm Res. .

Abstract

The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the occurrence and development of inflammation and tumor. Hepatic ischemia-reperfusion injury (HIRI) is a common pathophysiological phenomenon that occurs in surgical procedures such as lobectomy and liver transplantation, which is characterized by severe inflammatory reaction after ischemia and reperfusion. In this review, we mainly discuss the role of p38, ERK1/2, JNK in MAPK family and TAK1 and ASK1 in MAPKKK family in HIRI, and try to find an effective treatment for HIRI.

Keywords: ischemia/reperfusion injury; liver; mitogen-activated protein kinases.

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Conflict of interest statement

The authors report no conflict of interest in this study.

Figures

Figure 1
Figure 1
MAPK-related signaling pathways involved in hepatic ischemia-reperfusion injury. p38, Jnk and ERK participate in the regulation of liver ischemia-reperfusion injury through death receptor pathway, mitochondrial apoptosis pathway, endoplasmic reticulum reactive apoptosis pathway and oxidative stress pathway, etc.
See this image and copyright information in PMC

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