Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct 2;10(1):175-186.
doi: 10.1016/j.gendis.2021.09.004. eCollection 2023 Jan.

Adipose-derived stem cells and obesity: The spear and shield relationship

Hong Yang  1 , Chaowei Li  1 , Yizhou Li  1 , Ruiqing Tai  1 , Chao Sun  1
Affiliations
Review

Adipose-derived stem cells and obesity: The spear and shield relationship

Hong Yang et al. Genes Dis. .

Abstract

With the transformation of modern lifestyles and population ageing, obesity has become a global epidemic, as one of the important threat to human health of chronic non-communicable diseases (NCD). Stem cell therapy seems promising as an alternative strategy for managing obesity and related metabolic problems. Adipose tissue-derived stem cells (ADSCs) have received widespread attention, which provides new ideas for the treatment of obesity and various metabolic-related diseases, due to their abundant reserves, easy acquisition, rapid expansion, and multi-directional differentiation potential, low immunogenicity and many other advantages. Accordingly, there seems to be a "shield and spear paradox" in the relationship between ADSCs and obesity. In this review, we emphatically summarized the role of ADSCs in the occurrence and development of obesity and related metabolic disease processes, in order to pave the way for clinical practice.

Keywords: Adipose-derived stem cells; Differentiation; Inflammation; Insulin resistance; Metabolic syndrome; Obesity.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Various classification methods for obesity to 2021.
Figure 2
Figure 2
The mechanism of metabolic syndrome caused by obesity.
Figure 3
Figure 3
The origins and obstacles between ADSCs and the occurrence and development of obesity.
Figure 4
Figure 4
The mechanism of obesogen on ADSCs.
Figure 5
Figure 5
The effect of obesity on ADSCs.
Figure 6
Figure 6
ADSCs are a trenchant edge in the treatment of obesity.
See this image and copyright information in PMC

References

    1. Afshin A., Forouzanfar M.H., Reitsma M.B., et al. GBD 2015 Obesity Collaborators Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27. - PMC - PubMed
    1. Gregor M.F., Hotamisligil G.S. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–445. - PubMed
    1. Saltiel A.R., Olefsky J.M. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017;127(1):1–4. - PMC - PubMed
    1. Kawai T., Autieri M.V., Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375–C391. - PMC - PubMed
    1. Berezin A.E., Berezin A.A., Lichtenauer M. Emerging role of adipocyte dysfunction in inducing heart failure among obese patients with prediabetes and known diabetes mellitus. Front Cardiovasc Med. 2020;7:e583175. - PMC - PubMed

LinkOut - more resources