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. 2023 Apr 3;21(1):67.
doi: 10.1186/s12964-023-01094-4.

Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review

Bo Chen  1 , Ke Ning  1 , Ming-Li Sun  1 , Xin-An Zhang  2
Affiliations

Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review

Bo Chen et al. Cell Commun Signal. .

Abstract

Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA other than surgery. The exploration of the mechanisms of occurrence is important in exploring other new and effective treatments for OA. The current evidence shows that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays a vital role in cytogenesis and is involved in OA progression. The terms "JAK2", "STAT3", and "Osteoarthritis"were used in a comprehensive literature search in PubMed to further investigate the relationship between the JAK2/STAT3 signaling pathway and OA. This review focuses on the role and mechanism of JAK2/STAT3 signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation. In addition, this review summarizes recent evidence of therapeutic approaches to treat OA by targeting the JAK2/STAT3 pathway to accelerate the translation of evidence into the progression of strategies for OA treatment. Video abstract.

Keywords: JAK2/STAT3; Mechanism; Osteoarthritis; Pathway; Targeted therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
The pathology of osteoarthritis. The pathology of OA is typically characterized by articular cartilage degeneration, subchondral bone sclerosis and synovial lesions. Cartilage degradation is caused by programmed cellular death (apoptosis, proliferation, and autophagy) or inflammatory response. ↑: up-regulation;↓: down-regulation (Created with BioRender.com.)
Fig. 2
Fig. 2
The JAK2/STAT3 signaling pathway interplayed with other signaling pathways in chondrocytes. Phosphorylated STAT3, activated by JAK2, is translocated to the nucleus, and interacting with NF-kB, AKt/PI3K, and MAPK signaling pathways, which are involved in articular cartilage degradation. (Created with BioRender.com.)
Fig. 3
Fig. 3
Relationship between JAK2/STAT3 signaling pathway and Osteoarthritis. Obesity, mechanical stress, and aging are risk factors for OA. The JAK2/STAT3 signaling pathway modifies the pathological process of OA by regulating related cytokines. ↑: up-regulation (Created with BioRender.com.)
Fig. 4
Fig. 4
Therapeutic approaches to regulate JAK2/STAT3 signaling pathway in osteoarthritis. MicroRNAs, Traditional Chinese Medicine, and small molecule compound inhibitors are important therapeutic approaches for regulating OA through the JAK2/STAT3 signaling pathway. (Created with BioRender.com.)
See this image and copyright information in PMC

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