More immunosuppressive, more immunotherapy responsive? A double-edged sword of HBV-induced immune response in HCC
- PMID: 37013921
- DOI: 10.1097/HEP.0000000000000393
More immunosuppressive, more immunotherapy responsive? A double-edged sword of HBV-induced immune response in HCC
Comment on
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Epigenetic regulation of HBV-specific tumor-infiltrating T cells in HBV-related HCC.Hepatology. 2023 Sep 1;78(3):943-958. doi: 10.1097/HEP.0000000000000369. Epub 2023 Apr 1. Hepatology. 2023. PMID: 36999652 Free PMC article.
References
-
- Curti BD, Faries MB. Recent advances in the treatment of melanoma. N Engl J Med. 2021;384:2229–2240.
-
- Haber PK, Puigvehi M, Castet F, Lourdusamy V, Montal R, Tabrizian P, et al. Evidence-based management of hepatocellular carcinoma: systematic review and meta-analysis of randomized controlled trials (2002-2020). Gastroenterology. 2021;161:879–898.
-
- Pfister D, Nunez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature. 2021;592:450–456.
-
- Lim CJ, Lee YH, Pan L, Lai L, Chua C, Wasser M, et al. Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma. Gut. 2019;68:916–927.
-
- Cheng Y, Gunasegaran B, Singh HD, Dutertre CA, Loh CY, Lim JQ, et al. Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma. Immunity. 2021;54:1825–1840 e1827.
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