The Management of Metastatic Castrate-Sensitive Prostate Cancer: From Guidelines to Real-World Practice
- PMID: 37014098
- PMCID: PMC10485290
- DOI: 10.1093/oncolo/oyad047
The Management of Metastatic Castrate-Sensitive Prostate Cancer: From Guidelines to Real-World Practice
Abstract
This commentary highlights 2 international studies on real-world treatment trends and patterns among patients with metastatic castration-sensitive and resistant prostate cancer and how interventions targeting physicians and patients can bridge the gap between evidence-based medicine and real-world practice.
Conflict of interest statement
Neeraj Agarwal reports consultancy (lifetime association) to Astellas, AstraZeneca, Aveo, Bayer, Bristol Myers Squibb, Calithera, Clovis, Eisai, Eli Lilly, EMD Serono, Exelixis, Foundation Medicine, Genentech, Gilead, Janssen, Merck, MEI Pharma, Nektar, Novartis, Pfizer, Pharmacyclics, and Seattle Genetics; and also reports institutional research funding from AstraZeneca, Bavarian Nordic, Bayer, Bristol Myers Squibb, Calithera, Celldex, Clovis, Eisai, Eli Lilly, EMD Serono, Exelixis, Genentech, GlaxoSmithKline, Immunomedics, Janssen, Medivation, Merck, Nektar, New Link Genetics, Novartis, Pfizer, Prometheus, Rexahn, Roche, Sanofi, Seattle Genetics, Takeda, and Tracon. Umang Swami reports consultancy to Astellas, Exelixis, Seattle Genetics, Imvax, AstraZeneca, and Sanofi and research funding to institute from Janssen, Exelixis, and Astellas/Seattle Genetics. The other authors indicated no financial relationships.
Comment on
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Real-World Treatment Patterns Among Patients With Metastatic Castration-Resistant Prostate Cancer: Results From an International Study.Oncologist. 2023 Sep 7;28(9):e737-e747. doi: 10.1093/oncolo/oyad046. Oncologist. 2023. PMID: 37014097 Free PMC article.
References
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- Fizazi K, Tran N, Fein L, et al. . Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind, phase 3 trial. Lancet Oncol. 2019;20(5):686-700. 10.1016/S1470-2045(19)30082-8. - DOI - PubMed
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